Description
| 抗体名: | MAML1 Antibody, HRP conjugated (PACO46887) |
| 抗体コード: | PACO46887 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Mastermind-like protein 1 protein (1-45AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | HRP |
| バックグラウンド: | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. |
| シノニム: | Mastermind-like protein 1 (Mam-1), MAML1, KIAA0200 |
| UniProt Protein Function: | MAML1: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Interacts (via N-terminus) with NOTCH1, NOTCH2, NOTCH3 and NOTCH4 (via ankyrin repeat region). Interacts (via N-terminus) with p53 (via DNA-binding region). Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1. Also binds CREBBP/CBP and CDK8. Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. Belongs to the mastermind family. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 5q35 Cellular Component: intracellular membrane-bound organelle; nucleoplasm; nucleus Molecular Function:peptide antigen binding; protein binding; protein kinase binding; transcription coactivator activity Biological Process: activation of Notch receptor target transcription factor; Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; transcription initiation from RNA polymerase II promoter |
| NCBI Summary: | This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92585 |
| NCBI GenInfo Identifier: | 68565602 |
| NCBI Gene ID: | 9794 |
| NCBI Accession: | Q92585.3 |
| UniProt Secondary Accession: | Q92585,Q9NZ12, |
| UniProt Related Accession: | Q92585 |
| Molecular Weight: | 108,054 Da |
| NCBI Full Name: | Mastermind-like protein 1 |
| NCBI Synonym Full Names: | mastermind like transcriptional coactivator 1 |
| NCBI Official Symbol: | MAML1 |
| NCBI Official Synonym Symbols: | Mam1; Mam-1 |
| NCBI Protein Information: | mastermind-like protein 1 |
| UniProt Protein Name: | Mastermind-like protein 1 |
| UniProt Gene Name: | MAML1 |
| UniProt Entry Name: | MAML1_HUMAN |
