The LZTFL1 Polyclonal Antibody (PAC048158) is a valuable tool for researchers studying the LZTFL1 protein, which has been implicated in various cellular processes, including ciliary function and protein trafficking. This antibody is produced in rabbits and has been validated for use in Western blot applications, enabling detection and analysis of LZTFL1 in human samples.LZTFL1, also known as leucine zipper transcription factor-like 1, is known to interact with proteins involved in ciliary transport and signaling pathways, making it an important target for research in the fields of cell biology and neurobiology.
Dysregulation of LZTFL1 has been linked to ciliary dysfunction and various diseases, including ciliopathies and cancer, making it a promising candidate for therapeutic interventions.By using the PAC048158 antibody, researchers can gain insights into the role of LZTFL1 in cellular processes and disease pathology, paving the way for the development of new treatment strategies and potential therapeutic targets. This antibody is a valuable tool for studying LZTFL1 and its functions in both normal and disease states.
Western Blot. Positive WB detected in: HEK293 whole cell lysate, HepG2 whole cell lysate, Hela whole cell lysate, U251 whole cell lysate. All lanes: LZTFL1 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 35, 33, 30 kDa. Observed band size: 35, 50 kDa..
Immunofluorescent analysis of U251 cells using PACO48158 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human testis tissue using PACO48158 at dilution of 1:100.
Background:
Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
Synonyms:
Leucine zipper transcription factor-like protein 1, LZTFL1
UniProt Protein Function:
LZTFL1: Belongs to the LZTFL1 family.Chromosomal Location of Human Ortholog: 3p21.3Cellular Component: cytosolMolecular Function: identical protein binding; protein binding; protein complex bindingDisease: Bardet-biedl Syndrome 17
UniProt Protein Details:
NCBI Summary:
This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2013]
