Description
| 抗体名: | LRRC32 Antibody (PACO35514) |
| 抗体コード: | PACO35514 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Transforming growth factor β activator LRRC32 protein (301-500AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO35514 at dilution of 1:100. |
| バックグラウンド: | Key regulator of transforming growth factor β (TGFB1, TGFB2 and TGFB3) that controls TGF-β activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-β. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-β. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity). |
| シノニム: | Transforming growth factor β activator LRRC32 (Garpin) (Glycoprotein A repetitions predominant) (GARP) (Leucine-rich repeat-containing protein 32), LRRC32, D11S833E |
| UniProt Protein Function: | LRRC32: |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 11q13.5-q14 Cellular Component: integral to plasma membrane |
| NCBI Summary: | This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14392 |
| NCBI GenInfo Identifier: | 2498405 |
| NCBI Gene ID: | 2615 |
| NCBI Accession: | Q14392.1 |
| UniProt Secondary Accession: | Q14392,Q86V06, |
| UniProt Related Accession: | Q14392 |
| Molecular Weight: | 71,979 Da |
| NCBI Full Name: | Leucine-rich repeat-containing protein 32 |
| NCBI Synonym Full Names: | leucine rich repeat containing 32 |
| NCBI Official Symbol: | LRRC32 |
| NCBI Official Synonym Symbols: | GARP; D11S833E |
| NCBI Protein Information: | leucine-rich repeat-containing protein 32 |
| UniProt Protein Name: | Leucine-rich repeat-containing protein 32 |
| UniProt Synonym Protein Names: | Garpin; Glycoprotein A repetitions predominant; GARP |
| Protein Family: | Leucine-rich repeat-containing protein |
| UniProt Gene Name: | LRRC32 |
| UniProt Entry Name: | LRC32_HUMAN |
| Antibodies |
| Anti-LRRC32 Antibody (CAB16858) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
