Description
| 抗体名: | LPCAT2 Antibody (PACO10280) |
| 抗体コード: | PACO10280 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human LPCAT2 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | lysophosphatidylcholine acyltransferase 2;LPCAT2;AYTL1;DKFZp686H22112;FLJ20481;LysoPAFAT ; |
| UniProt Protein Function: | AYTL1: Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso- PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-alkyl-phosphatidylcholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.3.1.23; EC 2.3.1.67; Acetyltransferase; Membrane protein, integral; EC 2.3.1.51 Chromosomal Location of Human Ortholog: 16q12.2 Cellular Component: Golgi membrane; endoplasmic reticulum membrane; Golgi stack; endoplasmic reticulum; integral to membrane; lipid particle Molecular Function:1-alkylglycerophosphocholine O-acetyltransferase activity; 1-acylglycerophosphocholine O-acyltransferase activity; calcium ion binding; 1-acylglycerol-3-phosphate O-acyltransferase activity Biological Process: platelet activating factor biosynthetic process; phospholipid metabolic process; glycerophospholipid biosynthetic process |
| NCBI Summary: | This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009] |
| UniProt Code: | Q7L5N7 |
| NCBI GenInfo Identifier: | 74738601 |
| NCBI Gene ID: | 54947 |
| NCBI Accession: | Q7L5N7.1 |
| UniProt Secondary Accession: | Q7L5N7,Q6MZJ6, Q9NX23, A3KBM1, |
| UniProt Related Accession: | Q7L5N7 |
| Molecular Weight: | 544 |
| NCBI Full Name: | Lysophosphatidylcholine acyltransferase 2 |
| NCBI Synonym Full Names: | lysophosphatidylcholine acyltransferase 2 |
| NCBI Official Symbol: | LPCAT2 |
| NCBI Official Synonym Symbols: | AYTL1; LysoPAFAT |
| NCBI Protein Information: | lysophosphatidylcholine acyltransferase 2; LPCAT-2; 1-AGPAT 11; LPAAT-alpha; LPC acyltransferase 2; acyltransferase like 1; acyltransferase-like 1; 1-AGP acyltransferase 11; lysoPC acyltransferase 2; lyso-PAF acetyltransferase; acetyl-CoA:lyso-PAF acetyltransferase; lysophosphatidic acid acyltransferase alpha; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerol-3-phosphate O-acyltransferase 11; 1-alkylglycerophosphocholine O-acetyltransferase; acyl-CoA:lysophosphatidylcholine acyltransferase 2; lyso-platelet-activating factor (PAF) acetyltransferase; acetyl-CoA:lyso-platelet-activating factor acetyltransferase |
| UniProt Protein Name: | Lysophosphatidylcholine acyltransferase 2 |
| UniProt Synonym Protein Names: | 1-acylglycerol-3-phosphate O-acyltransferase 11 (EC:2.3.1.51); 1-AGP acyltransferase 11; 1-AGPAT 11; 1-acylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67); Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Acetyl-CoA:lyso-PAF acetyltransferase; Lyso-PAF acetyltransferase; LysoPAFAT; Acyltransferase-like 1; Lysophosphatidic acid acyltransferase alpha; LPAAT-alpha |
| Protein Family: | Lysophosphatidylcholine acyltransferase |
| UniProt Gene Name: | LPCAT2 |
| UniProt Entry Name: | PCAT2_HUMAN |
