Description
| 抗体名: | LATS2 Antibody |
| 抗体コード: | PACO03846 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC, IF |
| 推奨される希釈: | IHC:1:100-1:300, IF:1:200-1:1000 |
| 反応性: | Human, Mouse |
| 免疫原: | synthesized peptide derived from the Internal region of human Kpm. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | LATS2; KPM; Serine/threonine-protein kinase LATS2; Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog 2; Serine/threonine-protein kinase kpm; Warts-like kinase |
| UniProt Protein Function: | LATS2: an AGC kinase of the NDR family of kinases. A tumor suppressor of the LATS family. Plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Inhibits cell growth at the G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Interacts with and is phosphorylated by STK6. Ectopic expression induces apoptosis in lung cancer cell lines. Negatively regulates androgen receptor, and is downregulated in prostate cancer |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Kinase, protein; Tumor suppressor; Protein kinase, AGC; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; NDR family Chromosomal Location of Human Ortholog: 13q12.11 Cellular Component: cytoplasm; cytosol; microtubule organizing center; nucleus; spindle pole Molecular Function:ATP binding; protein binding; protein serine/threonine kinase activity Biological Process: G1/S transition of mitotic cell cycle; hormone-mediated signaling; negative regulation of cyclin-dependent protein kinase activity; peptidyl-serine phosphorylation; positive regulation of apoptosis; protein amino acid phosphorylation; regulation of organ growth |
| NCBI Summary: | This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NRM7 |
| NCBI GenInfo Identifier: | 212276441 |
| NCBI Gene ID: | 26524 |
| NCBI Accession: | Q9NRM7.2 |
| UniProt Secondary Accession: | Q9NRM7,Q9P2X1, B1AM47, |
| UniProt Related Accession: | Q9NRM7 |
| Molecular Weight: | 120,136 Da |
| NCBI Full Name: | Serine/threonine-protein kinase LATS2 |
| NCBI Synonym Full Names: | large tumor suppressor kinase 2 |
| NCBI Official Symbol: | LATS2 |
| NCBI Official Synonym Symbols: | KPM |
| NCBI Protein Information: | serine/threonine-protein kinase LATS2 |
| UniProt Protein Name: | Serine/threonine-protein kinase LATS2 |
| UniProt Synonym Protein Names: | Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog 2; Serine/threonine-protein kinase kpm; Warts-like kinase |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | LATS2 |
| UniProt Entry Name: | LATS2_HUMAN |
