Description
| 抗体名: | KYNU Antibody, Biotin conjugated (PACO46549) |
| 抗体コード: | PACO46549 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Kynureninase protein (99-214AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Biotin |
| バックグラウンド: | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid, (AA) and 3-hydroxyanthranilic acid, (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. |
| シノニム: | Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase), KYNU |
| UniProt Protein Function: | KYNU: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively. Belongs to the kynureninase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.7.1.3; Mitochondrial; Amino Acid Metabolism - tryptophan; Hydrolase Chromosomal Location of Human Ortholog: 2q22.2 Cellular Component: nucleoplasm; mitochondrion; cytoplasm; cytosol Molecular Function:protein homodimerization activity; kynureninase activity; pyridoxal phosphate binding Biological Process: anthranilate metabolic process; tryptophan catabolic process to acetyl-CoA; tryptophan catabolic process to kynurenine; quinolinate biosynthetic process; tryptophan catabolic process Disease: Hydroxykynureninuria |
| NCBI Summary: | Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010] |
| UniProt Code: | Q16719 |
| NCBI GenInfo Identifier: | 3913982 |
| NCBI Gene ID: | 8942 |
| NCBI Accession: | Q16719.1 |
| UniProt Secondary Accession: | Q16719,Q6I9T2, Q9BVW3, B2RCZ5, D3DP79, |
| UniProt Related Accession: | Q16719 |
| Molecular Weight: | 34,635 Da |
| NCBI Full Name: | Kynureninase |
| NCBI Synonym Full Names: | kynureninase |
| NCBI Official Symbol: | KYNU |
| NCBI Protein Information: | kynureninase; KYNU; L-kynurenine hydrolase |
| UniProt Protein Name: | Kynureninase |
| UniProt Synonym Protein Names: | L-kynurenine hydrolase |
| UniProt Gene Name: | KYNU |
| UniProt Entry Name: | KYNU_HUMAN |
