Description
| 抗体名: | KSR2 Antibody (PACO23257) |
| 抗体コード: | PACO23257 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IF |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IF:1:100-1:500 |
| 反応性: | Human, Mouse |
| 免疫原: | Synthesized peptide derived from internal of human KSR2. |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from COS7, 293 and 3T3 cells, using KSR2 antibody. |
 | Immunofluorescence analysis of HeLa cells, using KSR2 antibody. |
| バックグラウンド: | Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. |
| シノニム: | hKSR2; Kinase suppressor of Ras 2; KSR2; |
| UniProt Protein Function: | KSR2: Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, TKL; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); TKL group; RAF family Chromosomal Location of Human Ortholog: 12q24.22-q24.23 Cellular Component: cytoplasm; membrane Molecular Function:ATP binding; metal ion binding; protein serine/threonine kinase activity Biological Process: protein amino acid phosphorylation |
| UniProt Code: | Q6VAB6 |
| NCBI GenInfo Identifier: | 148886599 |
| NCBI Gene ID: | 283455 |
| NCBI Accession: | Q6VAB6.2 |
| UniProt Secondary Accession: | Q6VAB6,Q3B828, Q8N775, A0PJT2, |
| UniProt Related Accession: | Q6VAB6 |
| Molecular Weight: | 49,607 Da |
| NCBI Full Name: | Kinase suppressor of Ras 2 |
| NCBI Synonym Full Names: | kinase suppressor of ras 2 |
| NCBI Official Symbol: | KSR2 |
| NCBI Protein Information: | kinase suppressor of Ras 2 |
| UniProt Protein Name: | Kinase suppressor of Ras 2 |
| Protein Family: | Kinase suppressor of Ras |
| UniProt Gene Name: | KSR2 |
| UniProt Entry Name: | KSR2_HUMAN |
| Antibodies | ELISA Kits |
| Anti-KSR2 Antibody (CAB17866) | Human KSR2 ELISA Kit |
| KSR2 Antibody (PACO03921) | Human Kinase suppressor of Ras 2 (KSR2) ELISA Kit |
| KSR2 Colorimetric Cell-Based ELISA |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
