| UniProt Protein Function: | KIF13A: Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR- containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. Belongs to the kinesin-like protein family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Microtubule-binding; Motor Chromosomal Location of Human Ortholog: 6p23 Cellular Component: Golgi membrane; kinesin complex; microtubule; centrosome; trans-Golgi network membrane; endosome membrane; midbody Molecular Function:protein binding; microtubule binding; ATPase activity; microtubule motor activity; ATP binding Biological Process: intracellular protein transport; melanosome organization and biogenesis; metabolic process; Golgi to plasma membrane protein transport; cytokinesis; endosome to lysosome transport; microtubule-based movement |
| NCBI Summary: | This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q9H1H9 |
| NCBI GenInfo Identifier: | 157738625 |
| NCBI Gene ID: | 63971 |
| NCBI Accession: | NP_001099036.1 |
| UniProt Secondary Accession: | Q9H1H9,Q5THQ2, Q5THQ3, Q9H193, Q9H194, Q9H1H8, A0JP21 A0JP22, F2Z382, |
| UniProt Related Accession: | Q9H1H9 |
| Molecular Weight: | 7,726 Da |
| NCBI Full Name: | kinesin-like protein KIF13A isoform b |
| NCBI Synonym Full Names: | kinesin family member 13A |
| NCBI Official Symbol: | KIF13A |
| NCBI Official Synonym Symbols: | RBKIN; bA500C11.2 |
| NCBI Protein Information: | kinesin-like protein KIF13A |
| UniProt Protein Name: | Kinesin-like protein KIF13A |
| UniProt Synonym Protein Names: | Kinesin-like protein RBKIN |
| Protein Family: | Kinesin-like protein |
| UniProt Gene Name: | KIF13A |
| UniProt Entry Name: | KI13A_HUMAN |
