Description
| 抗体名: | KCNQ5 Antibody (PACO22516) |
| 抗体コード: | PACO22516 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| 反応性: | Human |
| 免疫原: | Synthesized peptide derived from internal of human KCNQ5. |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from Jurkat cells, using KCNQ5 antibody. |
| バックグラウンド: | Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M1 muscarinic receptors. |
| シノニム: | Potassium voltage-gated channel subfamily KQT member 5; Voltage-gated potassium channel subunit Kv7.5; Potassium channel subunit alpha KvLQT5; KQT-like 5; |
| UniProt Protein Function: | Kv7.5: Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.5/KCNQ5 sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral Chromosomal Location of Human Ortholog: 6q14 Cellular Component: clathrin coat; plasma membrane Molecular Function:delayed rectifier potassium channel activity; inward rectifier potassium channel activity; protein binding; voltage-gated potassium channel activity Biological Process: synaptic transmission |
| NCBI Summary: | This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
| UniProt Code: | Q9NR82 |
| NCBI GenInfo Identifier: | 122065285 |
| NCBI Gene ID: | 56479 |
| NCBI Accession: | Q9NR82.3 |
| UniProt Secondary Accession: | Q9NR82,Q17RE1, Q5VVP3, Q86W40, Q9NRN0, A6NKT6, A6PVT6 A8MSQ5, B4DS33, B5MC83, B7ZL37, F5GZV0, |
| UniProt Related Accession: | Q9NR82 |
| Molecular Weight: | 102,365 Da |
| NCBI Full Name: | Potassium voltage-gated channel subfamily KQT member 5 |
| NCBI Synonym Full Names: | potassium voltage-gated channel subfamily Q member 5 |
| NCBI Official Symbol: | KCNQ5 |
| NCBI Official Synonym Symbols: | Kv7.5 |
| NCBI Protein Information: | potassium voltage-gated channel subfamily KQT member 5 |
| UniProt Protein Name: | Potassium voltage-gated channel subfamily KQT member 5 |
| UniProt Synonym Protein Names: | KQT-like 5; Potassium channel subunit alpha KvLQT5; Voltage-gated potassium channel subunit Kv7.5 |
| Protein Family: | Potassium voltage-gated channel subfamily |
| UniProt Gene Name: | KCNQ5 |
| UniProt Entry Name: | KCNQ5_HUMAN |
