| UniProt Protein Function: | MYST2: a histone acetyltransferase that participates in DNA replication and the loading of the minichromosome maintenance (Mcm) complex onto chromatin. Is required for origin recognition complex (Orc) formation and replication licensing, and is responsible for much of the acetylation of histone H4. Interacts with MCM2 and ORC1L. Phosphorylated by Cdc2 during mitosis, creating a site that recruits Plk1, which in turn phosphorylates MYST2. Its phosphorylation by Plk1 during mitosis may be required for the formation of the prereplicative complex. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone. Specifically represses AR-mediated transcription. |
| UniProt Protein Details: | Protein type:EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Acetyltransferase Chromosomal Location of Human Ortholog: 17q21.32 Cellular Component: cytoplasm; histone acetyltransferase complex; nucleolus; nucleoplasm; nucleus Molecular Function:protein binding Biological Process: DNA replication |
| UniProt Code: | O95251 |
| NCBI GenInfo Identifier: | 68565854 |
| NCBI Gene ID: | 11143 |
| NCBI Accession: | O95251.1 |
| UniProt Secondary Accession: | O95251,B3KN74, B4DF85, B4DFB4, B4DFE0, B4DGY4, E7ER15 G5E9K7, |
| UniProt Related Accession: | O95251 |
| Molecular Weight: | 55,135 Da |
| NCBI Full Name: | Histone acetyltransferase KAT7 |
| NCBI Synonym Full Names: | lysine acetyltransferase 7 |
| NCBI Official Symbol: | KAT7 |
| NCBI Official Synonym Symbols: | HBO1; HBOA; MYST2; ZC2HC7 |
| NCBI Protein Information: | histone acetyltransferase KAT7 |
| UniProt Protein Name: | Histone acetyltransferase KAT7 |
| UniProt Synonym Protein Names: | Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST-2 |
| Protein Family: | Histone acetyltransferase |
| UniProt Gene Name: | KAT7 |
| UniProt Entry Name: | KAT7_HUMAN |
