Description
| 抗体名: | Itgal Antibody, FITC conjugated (PACO27686) |
| 抗体コード: | PACO27686 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Mouse |
| 免疫原: | Recombinant Mouse Integrin alpha-L protein (153-325AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | FITC |
| バックグラウンド: | Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Mice expressing a null mutation of the alpha-L subunit gene demonstrate impaired tumor rejection and impaired leukocytes recruitment. |
| シノニム: | Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 α chain) (LFA-1A) (Leukocyte function-associated molecule 1 α chain) (Lymphocyte antigen 15) (Ly-15) (CD antigen CD11a), Itgal, Lfa-1 Ly-15 |
| UniProt Protein Function: | ITGAL: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Belongs to the integrin alpha chain family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 7 F3|7 69.44 cM Cellular Component: cell surface; external side of plasma membrane; immunological synapse; intercellular junction; membrane Molecular Function:cell adhesion molecule binding; ICAM-3 receptor activity; protein complex binding; protein heterodimerization activity Biological Process: activated T cell proliferation; cell surface receptor linked signal transduction; cell-cell adhesion; cell-matrix adhesion; heterophilic cell adhesion; leukocyte adhesion; positive regulation of calcium-mediated signaling; positive regulation of cell-cell adhesion; positive regulation of T cell proliferation; receptor clustering; regulation of cell-cell adhesion; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
| UniProt Code: | P24063 |
| NCBI GenInfo Identifier: | 341940846 |
| NCBI Gene ID: | 16408 |
| NCBI Accession: | P24063.2 |
| UniProt Related Accession: | P24063 |
| Molecular Weight: | 21.7kD |
| NCBI Full Name: | Integrin alpha-L |
| NCBI Synonym Full Names: | integrin alpha L |
| NCBI Official Symbol: | Itgal |
| NCBI Official Synonym Symbols: | Cd11a; LFA-1; Ly-15; Ly-21; (p180); LFA-1A |
| NCBI Protein Information: | integrin alpha-L |
| UniProt Protein Name: | Integrin alpha-L |
| UniProt Synonym Protein Names: | CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; Lymphocyte antigen 15; Ly-15; CD_antigen: CD11a |
| Protein Family: | Integrin |
| UniProt Gene Name: | Itgal |
