Description
| 抗体名: | ITGA5 Antibody |
| 抗体コード: | PACO02250 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | WB:1:500-1:2000 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | synthesized peptide derived from the Internal region of human Integrin alpha5. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | ITGA5; FNRA; Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD49e |
| UniProt Protein Function: | ITGA5: Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV- 1 Tat. Belongs to the integrin alpha chain family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 12q11-q13 Cellular Component: cell surface; focal adhesion; intercellular junction; plasma membrane; ruffle Molecular Function:platelet-derived growth factor receptor binding; protein binding; vascular endothelial growth factor receptor 2 binding Biological Process: angiogenesis; cell adhesion; cell-substrate adhesion; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; leukocyte migration; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; wound healing, spreading of epidermal cells |
| NCBI Summary: | The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015] |
| UniProt Code: | P08648 |
| NCBI GenInfo Identifier: | 23831237 |
| NCBI Gene ID: | 3678 |
| NCBI Accession: | P08648.2 |
| UniProt Secondary Accession: | P08648,Q96HA5, |
| UniProt Related Accession: | P08648 |
| Molecular Weight: | 114,536 Da |
| NCBI Full Name: | Integrin alpha-5 |
| NCBI Synonym Full Names: | integrin subunit alpha 5 |
| NCBI Official Symbol: | ITGA5 |
| NCBI Official Synonym Symbols: | FNRA; CD49e; VLA-5; VLA5A |
| NCBI Protein Information: | integrin alpha-5 |
| UniProt Protein Name: | Integrin alpha-5 |
| UniProt Synonym Protein Names: | CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD_antigen: CD49e |
| Protein Family: | Integrin |
| UniProt Gene Name: | ITGA5 |
| UniProt Entry Name: | ITA5_HUMAN |
