| UniProt Protein Function: | IRF8: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Interacts (via C-terminus) with TRIM21 (via C-terminus). Interacts with COPS2. By IFNG/IFN-gamma. Predominantly expressed in lymphoid tissues. Belongs to the IRF family.Protein type: Transcription factor; DNA-bindingCellular Component: nucleoplasm; nucleusMolecular Function: protein binding; DNA binding; transcription factor activityBiological Process: positive regulation of interferon-gamma production; response to bacterium; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of interleukin-12 production; positive regulation of transcription, DNA-dependent; defense response to bacterium; immune response; myeloid cell differentiation; defense response to protozoan; phagocytosis |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P23611 |
| NCBI GenInfo Identifier: | 6680339 |
| NCBI Gene ID: | 15900 |
| NCBI Accession: | NP_032346.1 |
| UniProt Secondary Accession: | P23611 |
| UniProt Related Accession: | P23611 |
| Molecular Weight: | 48,237 Da |
| NCBI Full Name: | interferon regulatory factor 8 |
| NCBI Synonym Full Names: | interferon regulatory factor 8 |
| NCBI Official Symbol: | Irf8 |
| NCBI Official Synonym Symbols: | Myls; ICSBP; IRF-8; Icsbp1; AI893568 |
| NCBI Protein Information: | interferon regulatory factor 8; interferon consensus sequence-binding protein; interferon consensus sequence binding protein 1 |
| UniProt Protein Name: | Interferon regulatory factor 8 |
| UniProt Synonym Protein Names: | Interferon consensus sequence-binding protein; ICSBP |
| Protein Family: | Interferon regulatory factor |
| UniProt Gene Name: | Irf8 |
| UniProt Entry Name: | IRF8_MOUSE |
