The Interleukin-6 Polyclonal Antibody (CAB11114) is a valuable tool for researchers studying interleukin-6, a cytokine involved in inflammation and immune response regulation. This antibody, generated in rabbits, is highly specific for detecting interleukin-6 in human samples and is validated for Western blot applications. By binding to interleukin-6, this antibody allows for the accurate detection and analysis of this critical molecule in various cell types, making it an essential asset for studies in immunology, inflammation, and cancer research.Interleukin-6 is a key player in the body's response to infection, injury, and disease, with dysregulation of its signaling pathways implicated in various pathological conditions.
As a potent pro-inflammatory cytokine, interleukin-6 has been linked to the pathogenesis of numerous diseases, including autoimmune disorders, cardiovascular disease, and cancer. By targeting interleukin-6 with this antibody, researchers can gain insights into its role in disease development and progression, paving the way for the development of novel therapeutic strategies targeting this crucial cytokine.
Antibody Name:
IL6 Rabbit Polyclonal Antibody
Antibody SKU:
CAB11114
Antibody Size:
20uL, 50uL, 100uL
Application:
IHC
Reactivity:
Human, Mouse, Rat
Host Species:
Rabbit
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-212 of human IL6 (NP_000591.1).
Application:
IHC
Recommended Dilution:
IHC 1:50 - 1:100
Reactivity:
Human, Mouse, Rat
Positive Samples:
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-212 of human IL6 (NP_000591.1).
Purification Method:
Affinity purification
Storage Buffer:
Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants.
