Description
| 抗体名: | IMPDH2 Antibody, HRP conjugated (PACO27646) |
| 抗体コード: | PACO27646 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Inosine-5'-monophosphate dehydrogenase 2 protein (5-514AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | HRP |
| バックグラウンド: | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid, binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
| シノニム: | Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (IMPDH-II), IMPDH2, IMPD2 |
| UniProt Protein Function: | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
| NCBI Summary: | This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P12268 |
| NCBI GenInfo Identifier: | 124419 |
| NCBI Gene ID: | 3615 |
| NCBI Accession: | P12268.2 |
| UniProt Secondary Accession: | P12268,Q6LEF3, |
| UniProt Related Accession: | P12268 |
| Molecular Weight: | 55,805 Da |
| NCBI Full Name: | Inosine-5'-monophosphate dehydrogenase 2 |
| NCBI Synonym Full Names: | inosine monophosphate dehydrogenase 2 |
| NCBI Official Symbol: | IMPDH2 |
| NCBI Official Synonym Symbols: | IMPD2; IMPDH-II |
| NCBI Protein Information: | inosine-5'-monophosphate dehydrogenase 2 |
| UniProt Protein Name: | Inosine-5'-monophosphate dehydrogenase 2 |
| UniProt Synonym Protein Names: | IMPDH-II |
| UniProt Gene Name: | IMPDH2 |
