Description
| 抗体名: | IMPA1 Antibody (PACO09949) |
| 抗体コード: | PACO09949 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC, IF |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human IMPA1 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | inositol(myo)-1(or 4)-monophosphatase 1;IMPA1;IMPA ; |
| UniProt Protein Function: | IMPA1: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol- phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Belongs to the inositol monophosphatase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Phosphatase (non-protein); Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.94; EC 3.1.3.25 Chromosomal Location of Human Ortholog: 8q21.13-q21.3 Cellular Component: cytoplasm; cytosol Molecular Function:identical protein binding; protein homodimerization activity; manganese ion binding; inositol-1(or 4)-monophosphatase activity; magnesium ion binding; lithium ion binding Biological Process: inositol phosphate metabolic process; phosphoinositide phosphorylation; inositol phosphate dephosphorylation; inositol biosynthetic process; phosphatidylinositol biosynthetic process; signal transduction; phosphate metabolic process |
| NCBI Summary: | This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014] |
| UniProt Code: | P29218 |
| NCBI GenInfo Identifier: | 127717 |
| NCBI Gene ID: | 3612 |
| NCBI Accession: | P29218.1 |
| UniProt Secondary Accession: | P29218,Q9UK71, B2R733, B4DLN3, B7Z6Q4, J3KQT7, |
| UniProt Related Accession: | P29218 |
| Molecular Weight: | 277 |
| NCBI Full Name: | Inositol monophosphatase 1 |
| NCBI Synonym Full Names: | inositol(myo)-1(or 4)-monophosphatase 1 |
| NCBI Official Symbol: | IMPA1 |
| NCBI Official Synonym Symbols: | IMP; IMPA |
| NCBI Protein Information: | inositol monophosphatase 1; IMP 1; IMPase 1; inositol-1(or 4)-monophosphatase 1; D-galactose 1-phosphate phosphatase; lithium-sensitive myo-inositol monophosphatase A1 |
| UniProt Protein Name: | Inositol monophosphatase 1 |
| UniProt Synonym Protein Names: | D-galactose 1-phosphate phosphatase |
| Protein Family: | Inositol monophosphatase |
| UniProt Gene Name: | IMPA1 |
| UniProt Entry Name: | IMPA1_HUMAN |
