| UniProt Protein Function: | IL3RA: This is a receptor for interleukin-3. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xp22.3 or Yp11.3 Cellular Component: plasma membrane; integral to membrane Molecular Function:interleukin-3 receptor activity |
| NCBI Summary: | The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012] |
| UniProt Code: | P26951 |
| NCBI GenInfo Identifier: | 417184 |
| NCBI Gene ID: | 3563 |
| NCBI Accession: | P26951.1 |
| UniProt Related Accession: | P26951 |
| Molecular Weight: | |
| NCBI Full Name: | Interleukin-3 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 3 receptor subunit alpha |
| NCBI Official Symbol: | IL3RA |
| NCBI Official Synonym Symbols: | IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra |
| NCBI Protein Information: | interleukin-3 receptor subunit alpha |
| UniProt Protein Name: | Interleukin-3 receptor subunit alpha |
| UniProt Synonym Protein Names: | CD_antigen: CD123 |
| Protein Family: | Interleukin-3 receptor |
| UniProt Gene Name: | IL3RA |
| UniProt Entry Name: | IL3RA_HUMAN |
