| バックグラウンド: | Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. |
| シノニム: | Interleukin-37 (FIL1 zeta) (IL-1X) (Interleukin-1 family member 7) (IL-1F7) (Interleukin-1 homolog 4) (IL-1H) (IL-1H4) (Interleukin-1 zeta) (IL-1 zeta) (Interleukin-1-related protein) (IL-1RP1) (Interleukin-23) (IL-37), IL37, FIL1Z IL1F7 IL1H4 IL1RP1 |
| UniProt Protein Function: | IL37: Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. Belongs to the IL-1 family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine Chromosomal Location of Human Ortholog: 2q12-q14.1 Cellular Component: cytoplasm; cytosol; extracellular region; extracellular space; nucleolus; nucleus Molecular Function:cytokine activity; interleukin-1 receptor binding Biological Process: cytokine and chemokine mediated signaling pathway; immune response; inflammatory response to antigenic stimulus |
| NCBI Summary: | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NZH6 |
| NCBI GenInfo Identifier: | 25008593 |
| NCBI Gene ID: | 27178 |
| NCBI Accession: | Q9NZH6.1 |
| UniProt Secondary Accession: | Q9NZH6,Q56AP9, Q8TD04, Q8TD05, Q9HBF2, Q9HBF3, Q9UHA6 B5BU97, |
| UniProt Related Accession: | Q9NZH6 |
| Molecular Weight: | 17,459 Da |
| NCBI Full Name: | Interleukin-37 |
| NCBI Synonym Full Names: | interleukin 37 |
| NCBI Official Symbol: | IL37 |
| NCBI Official Synonym Symbols: | FIL1; FIL1Z; IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA) |
| NCBI Protein Information: | interleukin-37 |
| UniProt Protein Name: | Interleukin-37 |
| UniProt Synonym Protein Names: | FIL1 zeta; IL-1X; Interleukin-1 family member 7; IL-1F7; Interleukin-1 homolog 4; IL-1H; IL-1H4; Interleukin-1 zeta; IL-1 zeta; Interleukin-1-related protein; IL-1RP1; Interleukin-23; IL-37 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL37 |
| UniProt Entry Name: | IL37_HUMAN |
