Description
| 抗体名: | IL2RA Antibody (PACO53674) |
| 抗体コード: | PACO53674 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC, IF |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| 反応性: | Human, Rat |
| 免疫原: | Recombinant Human Interleukin-2 receptor subunit α protein (22-185AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat spleen tissue. All lanes: IL2RA antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 31 kDa. Observed band size: 31 kDa. |
 | Immunofluorescent analysis of HepG2 cells using PACO53674 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human glioma using PACO53674 at dilution of 1:100. |
| バックグラウンド: | Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. |
| シノニム: | Interleukin-2 receptor subunit α (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (TAC antigen) (p55) (CD antigen CD25), IL2RA |
| UniProt Protein Function: | IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 10p15.1 Cellular Component: plasma membrane Molecular Function:interleukin-2 binding; Ras guanyl-nucleotide exchange factor activity Biological Process: apoptosis; cell proliferation; cell surface receptor linked signal transduction; immune response; inflammatory response; MAPKKK cascade; regulation of T cell tolerance induction Disease: Diabetes Mellitus, Insulin-dependent, 10; Interleukin 2 Receptor, Alpha, Deficiency Of |
| NCBI Summary: | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009] |
| UniProt Code: | P01589 |
| NCBI GenInfo Identifier: | 124317 |
| NCBI Gene ID: | 3559 |
| NCBI Accession: | P01589.1 |
| UniProt Secondary Accession: | P01589,Q5W007, |
| UniProt Related Accession: | P01589 |
| Molecular Weight: | 30,819 Da |
| NCBI Full Name: | Interleukin-2 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 2 receptor subunit alpha |
| NCBI Official Symbol: | IL2RA |
| NCBI Official Synonym Symbols: | p55; CD25; IL2R; IMD41; TCGFR; IDDM10 |
| NCBI Protein Information: | interleukin-2 receptor subunit alpha |
| UniProt Protein Name: | Interleukin-2 receptor subunit alpha |
| UniProt Synonym Protein Names: | TAC antigen; p55; CD_antigen: CD25 |
| UniProt Gene Name: | IL2RA |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
