Description
| 抗体名: | IL2RA Antibody |
| 抗体コード: | PACO04143 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IF |
| 推奨される希釈: | WB:1:500-1:2000, IF:1:200-1:1000 |
| 反応性: | Human |
| 免疫原: | synthesized peptide derived from human IL-2Ralpha around the non-phosphorylation site of S268. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | IL2RA; Interleukin-2 receptor subunit alpha; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; TAC antigen; p55; CD antigen CD25 |
| UniProt Protein Function: | IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 10p15.1 Cellular Component: plasma membrane Molecular Function:interleukin-2 binding; Ras guanyl-nucleotide exchange factor activity Biological Process: apoptosis; cell proliferation; cell surface receptor linked signal transduction; immune response; inflammatory response; MAPKKK cascade; regulation of T cell tolerance induction Disease: Diabetes Mellitus, Insulin-dependent, 10; Interleukin 2 Receptor, Alpha, Deficiency Of |
| NCBI Summary: | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009] |
| UniProt Code: | P01589 |
| NCBI GenInfo Identifier: | 124317 |
| NCBI Gene ID: | 3559 |
| NCBI Accession: | P01589.1 |
| UniProt Secondary Accession: | P01589,Q5W007, |
| UniProt Related Accession: | P01589 |
| Molecular Weight: | 30,819 Da |
| NCBI Full Name: | Interleukin-2 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 2 receptor subunit alpha |
| NCBI Official Symbol: | IL2RA |
| NCBI Official Synonym Symbols: | p55; CD25; IL2R; IMD41; TCGFR; IDDM10 |
| NCBI Protein Information: | interleukin-2 receptor subunit alpha |
| UniProt Protein Name: | Interleukin-2 receptor subunit alpha |
| UniProt Synonym Protein Names: | TAC antigen; p55; CD_antigen: CD25 |
| UniProt Gene Name: | IL2RA |
