| UniProt Protein Function: | IL25: Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses. Belongs to the IL-17 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: extracellular space Molecular Function:cytokine activity; interleukin-17E receptor binding Biological Process: response to fungus; inflammatory response to antigenic stimulus; response to nematode; eosinophil differentiation; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q9H293 |
| NCBI GenInfo Identifier: | 20138730 |
| NCBI Gene ID: | 64806 |
| NCBI Accession: | Q9H293.1 |
| UniProt Secondary Accession: | Q9H293,Q2M3F0, Q8IZV3, Q8WXB0, |
| UniProt Related Accession: | Q9H293 |
| Molecular Weight: | 18,523 Da |
| NCBI Full Name: | Interleukin-25 |
| NCBI Synonym Full Names: | interleukin 25 |
| NCBI Official Symbol: | IL25 |
| NCBI Official Synonym Symbols: | IL17E |
| NCBI Protein Information: | interleukin-25; interleukin-17E |
| UniProt Protein Name: | Interleukin-25 |
| UniProt Synonym Protein Names: | Interleukin-17E; IL-17E |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL25 |
| UniProt Entry Name: | IL25_HUMAN |
