| UniProt Protein Function: | IL-1RA: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Belongs to the interleukin-1 receptor family. |
| UniProt Protein Details: | Protein type:EC 2.7.11.25; Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: 2q12 Cellular Component: integral to plasma membrane; membrane; plasma membrane Molecular Function:interleukin-1 receptor activity; platelet-derived growth factor receptor binding; protein binding; signal transducer activity; transmembrane receptor activity Biological Process: cell surface receptor linked signal transduction; immune response |
| NCBI Summary: | This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013] |
| UniProt Code: | P14778 |
| NCBI GenInfo Identifier: | 124308 |
| NCBI Gene ID: | 3554 |
| NCBI Accession: | P14778.1 |
| UniProt Secondary Accession: | P14778,Q587I7, |
| UniProt Related Accession: | P14778 |
| Molecular Weight: | 65,402 Da |
| NCBI Full Name: | Interleukin-1 receptor type 1 |
| NCBI Synonym Full Names: | interleukin 1 receptor type 1 |
| NCBI Official Symbol: | IL1R1 |
| NCBI Official Synonym Symbols: | P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha |
| NCBI Protein Information: | interleukin-1 receptor type 1 |
| UniProt Protein Name: | Interleukin-1 receptor type 1 |
| UniProt Synonym Protein Names: | CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha |
| Protein Family: | Interleukin-1 receptor |
| UniProt Gene Name: | IL1R1 |
| UniProt Entry Name: | IL1R1_HUMAN |
