| UniProt Protein Function: | Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971). |
| NCBI Summary: | Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014] |
| UniProt Code: | Q96F46 |
| NCBI GenInfo Identifier: | 116242517 |
| NCBI Gene ID: | 23765 |
| NCBI Accession: | Q96F46.2 |
| UniProt Secondary Accession: | Q96F46,O43844, Q20WK1, |
| UniProt Related Accession: | Q96F46 |
| Molecular Weight: | 92,153 Da |
| NCBI Full Name: | Interleukin-17 receptor A |
| NCBI Synonym Full Names: | interleukin 17 receptor A |
| NCBI Official Symbol: | IL17RA |
| NCBI Official Synonym Symbols: | CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R |
| NCBI Protein Information: | interleukin-17 receptor A |
| UniProt Protein Name: | Interleukin-17 receptor A |
| UniProt Synonym Protein Names: | CDw217; CD_antigen: CD217 |
| Protein Family: | Interleukin-17 receptor |
| UniProt Gene Name: | IL17RA |
