Description
| 抗体名: | IL12RB2 Antibody, Biotin conjugated (PACO57427) |
| 抗体コード: | PACO57427 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Interleukin-12 receptor subunit beta-2 protein (366-470AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Biotin |
| バックグラウンド: | Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-γ production. |
| シノニム: | Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2), IL12RB2 |
| UniProt Protein Function: | IL12RB2: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. Belongs to the type I cytokine receptor family. Type 2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, cytokine; Membrane protein, integral; Cell cycle regulation Chromosomal Location of Human Ortholog: 1p31.3-p31.2 Cellular Component: integral to plasma membrane; external side of plasma membrane Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein kinase binding Biological Process: positive regulation of interferon-gamma production; peptidyl-tyrosine phosphorylation; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation; interferon-gamma production; response to lipopolysaccharide |
| NCBI Summary: | The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | Q99665 |
| NCBI GenInfo Identifier: | 12229836 |
| NCBI Gene ID: | 3595 |
| NCBI Accession: | Q99665.1 |
| UniProt Secondary Accession: | Q99665,Q2M3V3, B1AN98, B7ZKL9, F5H7L6, |
| UniProt Related Accession: | Q99665 |
| Molecular Weight: | 87,484 Da |
| NCBI Full Name: | Interleukin-12 receptor subunit beta-2 |
| NCBI Synonym Full Names: | interleukin 12 receptor, beta 2 |
| NCBI Official Symbol: | IL12RB2 |
| NCBI Protein Information: | interleukin-12 receptor subunit beta-2; IL-12R subunit beta-2; IL-12 receptor subunit beta-2; interleukin-12 receptor beta-2 chain |
| UniProt Protein Name: | Interleukin-12 receptor subunit beta-2 |
| Protein Family: | Interleukin-12 receptor |
| UniProt Gene Name: | IL12RB2 |
| UniProt Entry Name: | I12R2_HUMAN |
