Description
| 抗体名: | IKZF3 Antibody (PACO43289) |
| 抗体コード: | PACO43289 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:200-1:1000 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Zinc finger protein Aiolos protein (280-450AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: Zinc finger protein Aiolos antibody at 8µg/ml + HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 59, 52, 54, 30, 48, 50, 55, 42, 36, 33, 43, 31 kDa. Observed band size: 59 kDa. |
| バックグラウンド: | Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. |
| シノニム: | Zinc finger protein Aiolos (Ikaros family zinc finger protein 3), IKZF3, ZNFN1A3 |
| UniProt Protein Function: | Aiolos: a transcription factor of the ikaros C2H2-type zinc-finger protein family. Plays an important role in the regulation of lymphocyte differentiation. Deletions in Aiolos have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 17q21 Cellular Component: cytoplasm; plasma membrane; nucleus Molecular Function:protein binding; protein homodimerization activity; protein heterodimerization activity; sequence-specific DNA binding; metal ion binding; transcription factor activity Biological Process: regulation of apoptosis; regulation of transcription from RNA polymerase II promoter; B cell activation; transcription, DNA-dependent; regulation of lymphocyte differentiation; regulation of B cell differentiation; regulation of B cell proliferation; mesoderm development |
| NCBI Summary: | This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012] |
| UniProt Code: | Q9UKT9 |
| NCBI GenInfo Identifier: | 212276437 |
| NCBI Gene ID: | 22806 |
| NCBI Accession: | Q9UKT9.2 |
| UniProt Secondary Accession: | Q9UKT9,Q69BL6, Q69BL7, Q69BL8, Q69BL9, Q69BM0, Q69BM1 Q69BM2, Q69BM3, Q69BM5, Q8N574, B4DVV5, |
| UniProt Related Accession: | Q9UKT9 |
| Molecular Weight: | 509 |
| NCBI Full Name: | Zinc finger protein Aiolos |
| NCBI Synonym Full Names: | IKAROS family zinc finger 3 (Aiolos) |
| NCBI Official Symbol: | IKZF3 |
| NCBI Official Synonym Symbols: | AIO; AIOLOS; ZNFN1A3 |
| NCBI Protein Information: | zinc finger protein Aiolos; zinc finger DNA binding protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos) |
| UniProt Protein Name: | Zinc finger protein Aiolos |
| UniProt Synonym Protein Names: | Ikaros family zinc finger protein 3 |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | IKZF3 |
| UniProt Entry Name: | IKZF3_HUMAN |
