Description
| 抗体名: | IGF2BP3 Antibody (PACO09893) |
| 抗体コード: | PACO09893 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human IGF2BP3 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | insulin-like growth factor 2 mRNA binding protein 3;IGF2BP3;DKFZp686F1078;IMP-3;IMP3;KOC1;VICKZ3 ; |
| UniProt Protein Function: | IGF2BP3: RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3'-UTR of CD44 mRNA. Belongs to the RRM IMP/VICKZ family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Spliceosome; Translation; RNA-binding Chromosomal Location of Human Ortholog: 7p11 Cellular Component: cytoplasm; cytosol; nucleus Molecular Function:protein binding; mRNA 3'-UTR binding; RNA binding; nucleotide binding; translation regulator activity; mRNA 5'-UTR binding Biological Process: anatomical structure morphogenesis; mRNA transport; translation; negative regulation of translation; gene expression; regulation of cytokine biosynthetic process |
| NCBI Summary: | The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00425 |
| NCBI GenInfo Identifier: | 254763311 |
| NCBI Gene ID: | 10643 |
| NCBI Accession: | O00425.2 |
| UniProt Secondary Accession: | O00425,Q63HM0, Q6MZZ2, Q86VB1, A0A4Z5, |
| UniProt Related Accession: | O00425 |
| Molecular Weight: | 579 |
| NCBI Full Name: | Insulin-like growth factor 2 mRNA-binding protein 3 |
| NCBI Synonym Full Names: | insulin-like growth factor 2 mRNA binding protein 3 |
| NCBI Official Symbol: | IGF2BP3 |
| NCBI Official Synonym Symbols: | KOC; CT98; IMP3; KOC1; IMP-3; VICKZ3 |
| NCBI Protein Information: | insulin-like growth factor 2 mRNA-binding protein 3; VICKZ family member 3; cancer/testis antigen 98; IGF2 mRNA-binding protein 3; IGF-II mRNA-binding protein 3; KH domain containing protein overexpressed in cancer |
| UniProt Protein Name: | Insulin-like growth factor 2 mRNA-binding protein 3 |
| UniProt Synonym Protein Names: | IGF-II mRNA-binding protein 3; KH domain-containing protein overexpressed in cancer; hKOC; VICKZ family member 3 |
| Protein Family: | Insulin-like growth factor 2 mRNA-binding protein |
| UniProt Gene Name: | IGF2BP3 |
| UniProt Entry Name: | IF2B3_HUMAN |
