Description
| 抗体名: | IDE Antibody, FITC conjugated (PACO47480) |
| 抗体コード: | PACO47480 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Insulin-degrading enzyme protein (501-800AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | FITC |
| バックグラウンド: | Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. |
| シノニム: | Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin), IDE |
| UniProt Protein Function: | IDE: Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. Belongs to the peptidase M16 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell surface; EC 3.4.24.56; Nuclear receptor co-regulator; Protease Chromosomal Location of Human Ortholog: 10q23.33 Cellular Component: cell surface; cytoplasm; cytosol; extracellular space; mitochondrion; nucleus; peroxisome Molecular Function:ATP binding; glycoprotein binding; insulin binding; metalloendopeptidase activity; peptide binding; protein binding; protein homodimerization activity; receptor binding; ubiquitin binding; zinc ion binding Biological Process: beta-amyloid metabolic process; determination of adult life span; positive regulation of protein oligomerization; protein homooligomerization; proteolysis; proteolysis involved in cellular protein catabolic process |
| NCBI Summary: | This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009] |
| UniProt Code: | P14735 |
| NCBI GenInfo Identifier: | 215274252 |
| NCBI Gene ID: | 3416 |
| NCBI Accession: | P14735.4 |
| UniProt Secondary Accession: | P14735,Q5T5N2, B2R721, B7ZAU2, D3DR35, |
| UniProt Related Accession: | P14735 |
| Molecular Weight: | 118kDa |
| NCBI Full Name: | Insulin-degrading enzyme |
| NCBI Synonym Full Names: | insulin degrading enzyme |
| NCBI Official Symbol: | IDE |
| NCBI Official Synonym Symbols: | INSULYSIN |
| NCBI Protein Information: | insulin-degrading enzyme |
| UniProt Protein Name: | Insulin-degrading enzyme |
| UniProt Synonym Protein Names: | Abeta-degrading protease; Insulin protease; Insulinase; Insulysin |
| Protein Family: | IgM protease |
| UniProt Gene Name: | IDE |
