Description
| Product Name: | Human ZNHIT1 Recombinant Protein |
| Product Code: | RPPB5188 |
| Size: | 20µg |
| Species: | Human |
| Target: | ZNHIT1 |
| Synonyms: | Zinc Finger HIT-Type Containing 1, ZNHIT1, ZNFN4A1, Zinc Finger Protein, Subfamily 4A (HIT Domain Containing) Member 1, Zinc Finger HIT Domain Containing 1, Putative Cyclin G1 Interacting Protein, Cyclin-G1-Binding Protein 1, Zinc Finger Protein Subfamily 4A Member 1, P18 Hamlet, CG1I, H_DJ0747G18.14, p18Hamlet, Zinc Finger HIT Domain-Containing Protein 1, Zinc Finger HIT Type 1, CGBP1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The ZNHIT1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMVEKKTS VRSQDPGQRR VLDRAARQRR INRQLEALEN DNFQDDPHAG LPQLGKRLPQ FDDDADTGKK KKKTRGDHFK LRFRKNFQAL LEEQNLSVAE GPNYLTACAG PPSRPQRPFC AVCGFPSPYT CVSCGARYCT VRCLGTHQET RCLKWTV |
Zinc Finger HIT-Type Containing 1 (ZNHIT1) is a member of the ZNHIT1 family and contains 1 HIT-type zinc finger. The ZNHIT1 protein is induced by DNA damage and appears to have a role in p53-mediated apoptosis induction. ZNHIT1 interacts with MAPK11 and MAPK14 and is a component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1. ZNHIT1 binds to NR1D2 and discharges it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity.
ZNHIT1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 177 amino acids (1-154) and having a molecular mass of 19.9kDa. ZNHIT1 is fused to a 23 amino acid His-tag at N-terminus.
| UniProt Protein Function: | ZNHIT1: Seems to play a role in p53-mediated apoptosis induction. Belongs to the ZNHIT1 family.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 7q22.1Cellular Component: nucleusMolecular Function: protein binding; histone deacetylase binding; metal ion binding; nucleosome bindingBiological Process: regulation of histone deacetylation; regulation of T cell proliferation; histone exchange; negative regulation of transcription from RNA polymerase II promoter |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O43257 |
| NCBI GenInfo Identifier: | 46397091 |
| NCBI Gene ID: | 10467 |
| NCBI Accession: | O43257.1 |
| UniProt Secondary Accession: | O43257,Q6IB12 |
| UniProt Related Accession: | O43257 |
| Molecular Weight: | 17,536 Da |
| NCBI Full Name: | Zinc finger HIT domain-containing protein 1 |
| NCBI Synonym Full Names: | zinc finger, HIT-type containing 1 |
| NCBI Official Symbol: | ZNHIT1�� |
| NCBI Official Synonym Symbols: | CG1I; ZNFN4A1�� |
| NCBI Protein Information: | zinc finger HIT domain-containing protein 1; H_DJ0747G18.14; cyclin-G1-binding protein 1; p18 Hamlet; p18Hamlet; putative cyclin G1 interacting protein; zinc finger protein subfamily 4A member 1; zinc finger protein, subfamily 4A (HIT domain containing), member 1; zinc finger, HIT domain containing 1; zinc finger, HIT type 1 |
| UniProt Protein Name: | Zinc finger HIT domain-containing protein 1 |
| UniProt Synonym Protein Names: | Cyclin-G1-binding protein 1; Zinc finger protein subfamily 4A member 1; p18 Hamlet |
| Protein Family: | Zinc finger HIT domain-containing protein |
| UniProt Gene Name: | ZNHIT1�� |
| UniProt Entry Name: | ZNHI1_HUMAN |
