Description
| Product Name: | Human ZCCHC12 Recombinant Protein |
| Product Code: | RPPB5176 |
| Size: | 20µg |
| Species: | Human |
| Target: | ZCCHC12 |
| Synonyms: | PNMA7A, SIZN, SIZN1, Zinc finger CCHC domain-containing protein 12, Smad-interacting zinc finger protein 1, ZCCHC12. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ZCCHC12 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMASIIAR VGNSRRLNAP LPPWAHSMLR SLGRSLGPIM ASMADRNMKL FSGRVVPAQG EETFENWLTQ VNGVLPDWNM SEEEKLKRLM KTLRGPAREV MRVLQATNPN LSVADFLRAM KLVFGESESS VTAHGKFFNT LQAQGEKASL YVIRLEVQLQ NAIQAGIIAE KDANRTRLQQ LLLGGELSRD LRLRLKDFLR MYANEQERLP NFLELIRMVR EEEDWDDAFI KRKRPKRSES MVERAVSPVA FQGSPPIVIG SADCNVIEID DTLDDSDEDV ILVESQDPPL PSWGAPPLRD RARPQDEVLV IDSPHNSRAQ FPSTSGGSGY KNNGPGEMRR ARKRKHTIRC SYCGEEGHSK ETCDNESDKA QVFENLIITL QELTHTEMER SRVAPGEYND FSEPL |
Zinc Finger, CCHC Domain Containing 12 (ZCCHC12) which holds 1 CCHC-type zinc finger is a part of the ZCCHC12 family. ZCCHC12 takes part in the bone morphogenetic protein (BMP)-signaling pathway as a transcriptional coactivator. BMP signaling is positively modulated as a result of the interaction between ZCCHC12 with SMAD1 and the association with CBP in the transcription complex.
ZCCHC12 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 425 amino acids (1-402 a.a) and having a molecular mass of 47.8kDa. ZCCHC12 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ZCCHC12: Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression. Belongs to the ZCCHC12 family. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: Xq24 Cellular Component: nuclear speck Molecular Function:ligand-dependent nuclear receptor transcription coactivator activity; protein binding Biological Process: BMP signaling pathway |
| NCBI Summary: | This gene encodes a downstream effector of bone morphogenetic protein (BMP) signalling. This protein contains a zinc finger domain and functions as a transcriptional coactivator. Variation in this gene may be associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] |
| UniProt Code: | Q6PEW1 |
| NCBI GenInfo Identifier: | 85718626 |
| NCBI Gene ID: | 170261 |
| NCBI Accession: | Q6PEW1.2 |
| UniProt Secondary Accession: | Q6PEW1,Q6PID5, Q8N1C1, B3KV48, |
| UniProt Related Accession: | Q6PEW1 |
| Molecular Weight: | 45,369 Da |
| NCBI Full Name: | Zinc finger CCHC domain-containing protein 12 |
| NCBI Synonym Full Names: | zinc finger CCHC-type containing 12 |
| NCBI Official Symbol: | ZCCHC12�� |
| NCBI Official Synonym Symbols: | SIZN; SIZN1; PNMA7A�� |
| NCBI Protein Information: | zinc finger CCHC domain-containing protein 12 |
| UniProt Protein Name: | Zinc finger CCHC domain-containing protein 12 |
| UniProt Synonym Protein Names: | Smad-interacting zinc finger protein 1 |
| Protein Family: | Zinc finger CCHC domain-containing protein |
| UniProt Gene Name: | ZCCHC12�� |
| UniProt Entry Name: | ZCH12_HUMAN |
