Description
| Product Name: | Human WBP2 Recombinant Protein |
| Product Code: | RPPB5145 |
| Size: | 10µg |
| Species: | Human |
| Target: | WBP2 |
| Synonyms: | WW domain binding protein 2, WBP-2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The WBP2 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 1mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMALNKNH SEGGGVIVNN TESILMSYDH VELTFNDMKN VPEAFKGTKK GTVYLTPYRV IFLSKGKDAM QSFMMPFYLM KDCEIKQPVF GANYIKGTVK AEAGGGWEGS ASYKLTFTAG GAIEFGQRML QVASQASRGE VPSGAYGYSY MPSGAYVYPP PVANGMYPCP PGYPYPPPPP EFYPGPPMMD GAMGYVQPPP PPYPGPMEPP VSGPDVPSTP AAEAKAAEAA ASAYYNPGNP HNVYMPTSQP PPPPYYPPED KKTQ |
WW domain-binding protein 2 (WBP2) is a steroid hormone receptor coactivator, which contains 1 GRAM domain. The globular WW domain is comprised of 38-40 semiconserved amino acids shared by proteins of various functions including structural, regulatory, and signaling proteins. This domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. WBP2 binds to the WW domain of Yes kinase-associated protein(YAP1) via its PY motifs.
WBP2 Human Recombinant produced in E. coli is a single polypeptide chain containing 284 amino acids (1-261) and having a molecular mass of 30.5 kDa.WBP2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | WBP2: Binds to the WW domain of YAP1, WWP1 and WWP2. Interacts with NEDD4. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Cell development/differentiation Chromosomal Location of Human Ortholog: 17q25 Cellular Component: nuclear chromatin Molecular Function:chromatin DNA binding; protein binding Biological Process: establishment of protein localization; positive regulation of gene expression, epigenetic; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q969T9 |
| NCBI GenInfo Identifier: | 25091539 |
| NCBI Gene ID: | 23558 |
| NCBI Accession: | Q969T9.1 |
| UniProt Secondary Accession: | Q969T9,O95638, |
| UniProt Related Accession: | Q969T9 |
| Molecular Weight: | 28,087 Da |
| NCBI Full Name: | WW domain-binding protein 2 |
| NCBI Synonym Full Names: | WW domain binding protein 2 |
| NCBI Official Symbol: | WBP2�� |
| NCBI Official Synonym Symbols: | WBP-2; GRAMD6�� |
| NCBI Protein Information: | WW domain-binding protein 2 |
| UniProt Protein Name: | WW domain-binding protein 2 |
| Protein Family: | WW domain-binding protein |
| UniProt Gene Name: | WBP2�� |
| UniProt Entry Name: | WBP2_HUMAN |
