Description
| Product Name: | Human VTI1B Recombinant Protein |
| Product Code: | RPPB5140 |
| Size: | 10µg |
| Species: | Human |
| Target: | VTI1B |
| Synonyms: | Vesicle transport through interaction with t-SNAREs homolog 1B, Vesicle transport v-SNARE protein Vti1-like 1, Vti1-rp1, VTI1B, VTI1, VTI1L, VTI1L1, VTI2, v-SNARE, VTI1-LIKE. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | VTI1B protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 30% glycerol, 0.15M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMASSAAS SEHFEKLHEI FRGLHEDLQG VPERLLGTAG TEEKKKLIRD FDEKQQEANE TLAEMEEELR YAPLSFRNPM MSKLRNYRKD LAKLHREVRS TPLTATPGGR GDMKYGIYAV ENEHMNRLQS QRAMLLQGTE SLNRATQSIE RSHRIATETD QIGSEIIEEL GEQRDQLERT KSRLVNTSEN LSKSRKILRS MSRKVTTNKL L |
VTI1B (v-SNARE) mediates vesicle transport pathways via interactions with t-SNAREs on the target membrane. These interactions are meant to facilitate aspects of the specificity of vesicle trafficking and to stimulate fusion of the lipid bilayers. VTI1B may be involved in increased secretion of cytokines connected with cellular senescence.
VTI1B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 231 amino acids (1-208 a.a) and having a molecular mass of 26.3kDa (Molecular weight on SDS-PAGE will appear higher).VTI1B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | VTI1B: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. Belongs to the VTI1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Vesicle Chromosomal Location of Human Ortholog: 14q24.1 Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; intracellular membrane-bound organelle; late endosome membrane; lysosomal membrane; integral to membrane; SNARE complex; synaptic vesicle; recycling endosome; cell soma; perinuclear region of cytoplasm; cytoplasm; vesicle Molecular Function:SNAP receptor activity; SNARE binding; chloride channel inhibitor activity Biological Process: vesicle-mediated transport; intra-Golgi vesicle-mediated transport; cell proliferation; ER to Golgi vesicle-mediated transport; autophagic vacuole fusion; Golgi to vacuole transport; vesicle fusion with Golgi apparatus; protein targeting to vacuole; retrograde transport, endosome to Golgi; vesicle docking during exocytosis |
| UniProt Code: | Q9UEU0 |
| NCBI GenInfo Identifier: | 126302613 |
| NCBI Gene ID: | 10490 |
| NCBI Accession: | Q9UEU0.3 |
| UniProt Secondary Accession: | Q9UEU0,O43547, Q96J28, |
| UniProt Related Accession: | Q9UEU0 |
| Molecular Weight: | 232 |
| NCBI Full Name: | Vesicle transport through interaction with t-SNAREs homolog 1B |
| NCBI Synonym Full Names: | vesicle transport through interaction with t-SNAREs 1B |
| NCBI Official Symbol: | VTI1B�� |
| NCBI Official Synonym Symbols: | VTI1; VTI2; VTI1L; v-SNARE; vti1-rp1; VTI1-LIKE�� |
| NCBI Protein Information: | vesicle transport through interaction with t-SNAREs homolog 1B; vesicle transport v-SNARE protein Vti1-like 1; vesicle-associated soluble NSF attachment protein receptor |
| UniProt Protein Name: | Vesicle transport through interaction with t-SNAREs homolog 1B |
| UniProt Synonym Protein Names: | Vesicle transport v-SNARE protein Vti1-like 1; Vti1-rp1 |
| Protein Family: | Vesicle transport through interaction with t-SNAREs |
| UniProt Gene Name: | VTI1B�� |
| UniProt Entry Name: | VTI1B_HUMAN |
