Description
| Product Name: | Human VAMP3 Recombinant Protein |
| Product Code: | RPPB5105 |
| Size: | 25µg |
| Species: | Human |
| Target: | VAMP3 |
| Synonyms: | VAMP3, VAMP-3, Cellubrevin, Vesicle-Associated Membrane Protein 3, Synaptobrevin-3, CEB, SYB3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The VAMP3 protein solution contains 20mM Tris pH-7.5 and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MSTGPTAATG SNRRLQQTQN QVDEVVDIMR VNVDKVLERD QKLSELDDRA DALQAGASQF ETSAAKLKRK YWWKNCK |
VAMP3 is present in recycling endosomes and endosome-derived vesicles. VAMP3 has been implicated in recycling of transferrin receptors to the plasma membrane, secretion of alpha-granules in platelets, recycling of T-cell receptors to the immunological synapses, and membrane trafficking during cell migration. VAMP-3 is present in human platelets and necessary for granule secretion. Synaptobrevins are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP3 high homology to other VAMPs in its broad tissue distribution and subcellular localization is shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.
VAMP3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 77 amino acids and having a molecular mass of 8.7 kDa.
| UniProt Protein Function: | VAMP3: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. Belongs to the synaptobrevin family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1p36.23 Cellular Component: neuron projection; cell surface; intracellular membrane-bound organelle; clathrin-coated vesicle; integral to membrane; clathrin coated vesicle membrane; cytosol; secretory granule; SNARE complex; synaptic vesicle; recycling endosome; apical plasma membrane; plasma membrane; intracellular; cell junction Molecular Function:SNAP receptor activity; SNARE binding; protein binding; syntaxin-1 binding Biological Process: vesicle fusion; vesicle-mediated transport; exocytosis; neurotransmitter secretion; Golgi to plasma membrane protein transport; protein complex assembly; positive regulation of immunoglobulin secretion; positive regulation of receptor recycling; retrograde transport, endosome to Golgi; vesicle docking during exocytosis; calcium ion-dependent exocytosis |
| NCBI Summary: | Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15836 |
| NCBI GenInfo Identifier: | 2501082 |
| NCBI Gene ID: | 9341 |
| NCBI Accession: | Q15836.3 |
| UniProt Secondary Accession: | Q15836,P63024, P63025, |
| UniProt Related Accession: | Q15836 |
| Molecular Weight: | |
| NCBI Full Name: | Vesicle-associated membrane protein 3 |
| NCBI Synonym Full Names: | vesicle associated membrane protein 3 |
| NCBI Official Symbol: | VAMP3�� |
| NCBI Official Synonym Symbols: | CEB�� |
| NCBI Protein Information: | vesicle-associated membrane protein 3 |
| UniProt Protein Name: | Vesicle-associated membrane protein 3 |
| UniProt Synonym Protein Names: | Cellubrevin; CEB; Synaptobrevin-3 |
| UniProt Gene Name: | VAMP3�� |
| UniProt Entry Name: | VAMP3_HUMAN |
