Description
| Product Name: | Human VAMP1 Recombinant Protein |
| Product Code: | RPPB5100 |
| Size: | 20µg |
| Species: | Human |
| Target: | VAMP1 |
| Synonyms: | Vesicle-associated membrane protein 1, SYB1, VAMP-1, Synaptobrevin-1, VAMP1, DKFZp686H12131. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The protein solution (1mg/ml) contains 1X PBS and 1mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined�by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MSAPAQPPAE GTEGTAPGGG PPGPPPNMTS NRRLQQTQAQVEEVVDIIRV NVDKVLERDQ KLSELDDRAD ALQAGASQFE SSAAKLKRKY W |
Synaptobrevin 1(Vehicle-associated membrane, VAMP1) is one of the key proteins in the SNARE complex which is involved in regulated exocytosis. Synaptobrevin1 binds to t-SNAREs, syntaxin (STX) and SNAP25, after the fusion of synaptic vesicles to plasma membrane.
VAMP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 111 amino acids (1-91) and having a molecular mass of 11.9 kDa. The VAMP-1 contains 20 amino acids His-Tag fused at N-terminus and purified by standard chromatography techniques.
| UniProt Protein Function: | VAMP1: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Belongs to the synaptobrevin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p Cellular Component: cell junction; cell surface; cytosol; integral to plasma membrane; mitochondrial outer membrane; synaptic vesicle membrane; terminal button Molecular Function:protein binding; SNAP receptor activity; SNARE binding Biological Process: vesicle fusion Disease: Spastic Ataxia 1, Autosomal Dominant |
| NCBI Summary: | Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014] |
| UniProt Code: | P23763 |
| NCBI GenInfo Identifier: | 135093 |
| NCBI Gene ID: | 6843 |
| NCBI Accession: | P23763.1 |
| UniProt Secondary Accession: | P23763,O75468, Q15857, Q6FG94, Q8IVC9, A8MVP3, D3DUR3 |
| UniProt Related Accession: | P23763 |
| Molecular Weight: | 12,658 Da |
| NCBI Full Name: | Vesicle-associated membrane protein 1 |
| NCBI Synonym Full Names: | vesicle associated membrane protein 1 |
| NCBI Official Symbol: | VAMP1�� |
| NCBI Official Synonym Symbols: | SYB1; SPAX1; VAMP-1�� |
| NCBI Protein Information: | vesicle-associated membrane protein 1 |
| UniProt Protein Name: | Vesicle-associated membrane protein 1 |
| UniProt Synonym Protein Names: | Synaptobrevin-1 |
| Protein Family: | Vesicle-associated membrane protein |
| UniProt Gene Name: | VAMP1�� |
| UniProt Entry Name: | VAMP1_HUMAN |
