Description
| Product Name: | Human UPK2 Recombinant Protein |
| Product Code: | RPPB5086 |
| Size: | 20µg |
| Species: | Human |
| Target: | UPK2 |
| Synonyms: | Uroplakin-2, UP2, Uroplakin II, UPII, UPK2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | UPK2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2M UREA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSDFNISSL SGLLSPALTE SLLVALPPCH LTGGNATLMV RRANDSKVVT SSFVVPPCRG RRELVSVVDS GAGFTVTRLS AYQVTNLVPG TKFYISYLVK KGTATESSRE IPMSTLPRRN MESIGLGMAR TGG |
Uroplakin 2 (UPK2) is one of the proteins of the highly urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is thought to strengthen the urothelium by preventing cell rupture during bladder distention. The UPK2 protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.
UPK2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids (26-155 a.a) and having a molecular mass of 16.2kDa.UPK2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | UPK2: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM. Belongs to the uroplakin-2 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 11q23 Cellular Component: integral to plasma membrane; apical plasma membrane; integral to endoplasmic reticulum membrane Biological Process: epithelial cell differentiation; multicellular organismal development |
| NCBI Summary: | This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009] |
| UniProt Code: | O00526 |
| NCBI GenInfo Identifier: | 6707761 |
| NCBI Gene ID: | 7379 |
| NCBI Accession: | O00526.2 |
| UniProt Secondary Accession: | O00526,O00457, Q53YV0, B0YJ92, |
| UniProt Related Accession: | O00526 |
| Molecular Weight: | 184 |
| NCBI Full Name: | Uroplakin-2 |
| NCBI Synonym Full Names: | uroplakin 2 |
| NCBI Official Symbol: | UPK2�� |
| NCBI Official Synonym Symbols: | UP2; UPII�� |
| NCBI Protein Information: | uroplakin-2; uroplakin II |
| UniProt Protein Name: | Uroplakin-2 |
| UniProt Synonym Protein Names: | Uroplakin II; UPII |
| Protein Family: | Uroplakin |
| UniProt Gene Name: | UPK2�� |
| UniProt Entry Name: | UPK2_HUMAN |
