Description
| Product Name: | Human UBLCP1 Recombinant Protein |
| Product Code: | RPPB5070 |
| Size: | 10µg |
| Species: | Human |
| Target: | UBLCP1 |
| Synonyms: | CPUB1, Ubiquitin-like domain-containing CTD phosphatase 1,Nuclear proteasome inhibitor UBLCP1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | UBLCP1 protein solution (0.25mg/ml)�in Phosphate buffered saline (pH7.4), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMALPIIV KWGGQEYSVT TLSEDDTVLD LKQFLKTLTG VLPERQKLLGLKVKGKPAEN DVKLGALKLK PNTKIMMMGT REESLEDVLG PPPDNDDVVN DFDIEDEVVE VENREENLLKISRRVKEYKV EILNPPREGK KLLVLDVDYT LFDHRSCAET GVELMRPYLH EFLTSAYEDY DIVIWSATNMKWIEAKMKEL GVSTNANYKI TFMLDSAAMI TVHTPRRGLI DVKPLGVIWG KFSEFYSKKN TIMFDDIGRNFLMNPQNGLK IRPFMKAHLN RDKDKELLKL TQYLKEIAKL DDFLDLNHKY WERYLSKKQG Q |
Ubiquitin-like domain-containing CTD phosphatase 1 (UBLCP1) dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation averts assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
UBLCP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 341 amino acids (1-318 a.a) and having a molecular mass of 39.2kDa.UBLCP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | UBLCP1: Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome. |
| UniProt Protein Details: | Protein type:Hydrolase; EC 3.1.3.16 Chromosomal Location of Human Ortholog: 5q33.3 Cellular Component: nucleolus; nucleus Molecular Function:protein binding; protein serine/threonine phosphatase activity Biological Process: protein amino acid dephosphorylation |
| UniProt Code: | Q8WVY7 |
| NCBI GenInfo Identifier: | 74751564 |
| NCBI Gene ID: | 134510 |
| NCBI Accession: | Q8WVY7.2 |
| UniProt Secondary Accession: | Q8WVY7,Q96DK5, D3DQJ7, |
| UniProt Related Accession: | Q8WVY7 |
| Molecular Weight: | 36,805 Da |
| NCBI Full Name: | Ubiquitin-like domain-containing CTD phosphatase 1 |
| NCBI Synonym Full Names: | ubiquitin like domain containing CTD phosphatase 1 |
| NCBI Official Symbol: | UBLCP1�� |
| NCBI Official Synonym Symbols: | CPUB1�� |
| NCBI Protein Information: | ubiquitin-like domain-containing CTD phosphatase 1 |
| UniProt Protein Name: | Ubiquitin-like domain-containing CTD phosphatase 1 |
| UniProt Synonym Protein Names: | Nuclear proteasome inhibitor UBLCP1 |
| Protein Family: | Ubiquitin-like domain-containing CTD phosphatase |
| UniProt Gene Name: | UBLCP1�� |
| UniProt Entry Name: | UBCP1_HUMAN |
