Description
| Product Name: | Human TXNL4A Recombinant Protein |
| Product Code: | RPPB5054 |
| Size: | 10µg |
| Species: | Human |
| Target: | TXNL4A |
| Synonyms: | Thioredoxin-like 4A, Spliceosomal U5 snRNP-specific 15 kDa protein, DIM1 protein homolog, HsT161, TXNL4, DIB1, U5-15kD. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The TXNL4A solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 200mM NaCl and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMSYMLP HLHNGWQVDQ AILSEEDRVV VIRFGHDWDP TCMKMDEVLY SIAEKVKNFA VIYLVDITEV PDFNKMYELY DPCTVMFFFR NKHIMIDLGT GNNNKINWAM EDKQEMVDII ETVYRGARKG RGLVVSPKDY STKYRY |
TXNL4A is a member of the Dim protein family and has a vital part in pre-mRNA splicing. As a result of a failure to express early zygotic transcripts, deletion of the gene encoding TXNL4A in Schizosaccharomyces pombe results in embryonal lethality during gastrulation. Restricted to the nucleus, TXNL4A cooperates with hnRNP F, hnRNP H2, Cas-L and PQBP-1 to influence gene expression.
TXNL4A Human Recombinant produced in E. coli is a single polypeptide chain containing 166 amino acids (1-142) and having a molecular mass of 19.3kDa.TXNL4A is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| NCBI Summary: | The protein encoded by this gene is a member of the U5 small ribonucleoprotein particle (snRNP), and is involved in pre-mRNA splicing. This protein contains a thioredoxin-like fold and it is expected to interact with multiple proteins. Protein-protein interactions have been observed with the polyglutamine tract-binding protein 1 (PQBP1). Mutations in both the coding region and promoter region of this gene have been associated with Burn-McKeown syndrome, which is a rare disorder characterized by craniofacial dysmorphisms, cardiac defects, hearing loss, and bilateral choanal atresia. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015] |
| UniProt Code: | P83876 |
| NCBI GenInfo Identifier: | 33875918 |
| NCBI Gene ID: | 10907 |
| NCBI Accession: | BC001046 |
| UniProt Secondary Accession: | P83876,O14834, B2RC18, |
| UniProt Related Accession: | P83876 |
| Molecular Weight: | 16,786 Da |
| NCBI Full Name: | Homo sapiens thioredoxin-like 4A, mRNA |
| NCBI Synonym Full Names: | thioredoxin like 4A |
| NCBI Official Symbol: | TXNL4A�� |
| NCBI Official Synonym Symbols: | BMKS; DIB1; DIM1; TXNL4; SNRNP15; U5-15kD�� |
| NCBI Protein Information: | thioredoxin-like protein 4A |
| UniProt Protein Name: | |
| Protein Family: | Thioredoxin-like protein |
| UniProt Gene Name: |
