Description
| Product Name: | Human TXNL1 Recombinant Protein |
| Product Code: | RPPB5053 |
| Size: | 20µg |
| Species: | Human |
| Target: | TXNL1 |
| Synonyms: | Thioredoxin-like protein 1, TRP32, Txl, 32 kDa thioredoxin-related protein, TXNL, Thioredoxin-like 32kDa, TXL-1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The TXNL1 protein solution (0.5mg/1ml) is formulated in 20 mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MVGVKPVGSD PDFQPELSGA GSRLAVVKFT MRGCGPCLRI APAFSSMSNK YPQAVFLEVD VHQCQGTAAT NNISATPTFL FFRNKVRIDQ YQGADAVGLE EKIKQHLEND PGSNEDTDIP KGYMDLMPFI NKAGCECLNE SDEHGFDNCL RKDTTFLESD CDEQLLITVA FNQPVKLYSM KFQGPDNGQG PKYVKIFINL PRSMDFEEAE RSEPTQALEL TEDDIKEDGI VPLRYVKFQN VNSVTIFVQS NQGEEETTRI SYFTFIGTPV QATNMNDFKR VVGKKGESH |
TXNL1 is a cytoplasmic protein which takes part in endocytotic signaling pathways and acts as a redox sensor. TXNL1 is universally expressed in the body and its goal is to couple oxidative stress to endocytosis, thereby regulating the GDI. Moreover, overexpression of TXNL1 inhibits cell proliferation by predisposing the cell to G0/G1 arrest, signifying that TXNL1 also functions as a transcriptional repressor.
TXNL1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 309 amino acids (1-289.a.a) and having a molecular mass of 34.4kDa. TXNL1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TXNL1: a thiol reductase and novel subunit of the proteasome 19S particle. Interconverts reduced sulfide groups and oxidized disulfide bonds in a substrate. |
| UniProt Protein Details: | Protein type:Oxidoreductase Chromosomal Location of Human Ortholog: 18q21.31 Cellular Component: cytoplasm; mitochondrion; nucleus; proteasome complex Molecular Function:disulfide oxidoreductase activity; oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; protein disulfide oxidoreductase activity Biological Process: cell redox homeostasis; glycerol ether metabolic process; protein folding; sulfate assimilation |
| UniProt Code: | O43396 |
| NCBI GenInfo Identifier: | 18202039 |
| NCBI Gene ID: | 9352 |
| NCBI Accession: | O43396.3 |
| UniProt Related Accession: | O43396 |
| Molecular Weight: | 32,251 Da |
| NCBI Full Name: | Thioredoxin-like protein 1 |
| NCBI Synonym Full Names: | thioredoxin like 1 |
| NCBI Official Symbol: | TXNL1�� |
| NCBI Official Synonym Symbols: | Txl; TXNL; TRP32; TXL-1; HEL-S-114�� |
| NCBI Protein Information: | thioredoxin-like protein 1 |
| UniProt Protein Name: | Thioredoxin-like protein 1 |
| UniProt Synonym Protein Names: | 32 kDa thioredoxin-related protein |
| Protein Family: | Thioredoxin |
| UniProt Gene Name: | TXNL1�� |
| UniProt Entry Name: | TXNL1_HUMAN |
