Description
| Product Name: | Human TXNDC12 Recombinant Protein |
| Product Code: | RPPB5051 |
| Size: | 10µg |
| Species: | Human |
| Target: | TXNDC12 |
| Synonyms: | Thioredoxin domain containing 12 (endoplasmic reticulum), Endoplasmic reticulum resident protein 18, Endoplasmic reticulum resident protein 19, endoplasmic reticulum thioredoxin superfamily member 18 kDa, thioredoxin domain-containing protein 12, protein disulfide isomerase family A member 16, endoplasmic reticulum protein ERp19, anterior gradient homolog 1, Thioredoxin-like protein p19, ER protein 18, ERP18, ER protein 19, ERP19, ERP16, TLP19, AGR1, PDIA16, hAG-1, EC 1.8.4.2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The TXNDC12 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMHN GLGKGFGDHI HWRTLEDGKK EAAASGLPLM VIIHKSWCGA CKALKPKFAE STEISELSHN FVMVNLEDEE EPKDEDFSPD GGYIPRILFL DPSGKVHPEI INENGNPSYK YFYVSAEQVV QGMKEAQERL TGDAFRKKHL EDEL |
TXNDC12 is a member of the thioredoxin super family. This Family members have a thioredoxin fold with a consensus active-site sequence (CxxC) and take part in redox regulation, protection against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors.
TXNDC12 Human Recombinant produced in E. coli is a single polypeptide chain containing 184 amino acids (27-172) and having a molecular mass of 20.8 kDa.TXNDC12 is fused to a 38 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TXNDC12: Possesses significant protein thiol-disulfide oxidase activity. |
| UniProt Protein Details: | Protein type:Secreted; Other Amino Acids Metabolism - glutathione; Oxidoreductase; Secreted, signal peptide; EC 1.8.4.2 Chromosomal Location of Human Ortholog: 1p32.3 Cellular Component: endoplasmic reticulum lumen Molecular Function:peptide disulfide oxidoreductase activity; protein binding |
| NCBI Summary: | This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012] |
| UniProt Code: | O95881 |
| NCBI GenInfo Identifier: | 29839456 |
| NCBI Gene ID: | 51060 |
| NCBI Accession: | O95881.1 |
| UniProt Secondary Accession: | O95881,Q5T1T4, Q96H50, B3KQS0, |
| UniProt Related Accession: | O95881 |
| Molecular Weight: | 19,206 Da |
| NCBI Full Name: | Thioredoxin domain-containing protein 12 |
| NCBI Synonym Full Names: | thioredoxin domain containing 12 |
| NCBI Official Symbol: | TXNDC12�� |
| NCBI Official Synonym Symbols: | AG1; AGR1; ERP16; ERP18; ERP19; TLP19; hAG-1; PDIA16; hTLP19�� |
| NCBI Protein Information: | thioredoxin domain-containing protein 12 |
| UniProt Protein Name: | Thioredoxin domain-containing protein 12 |
| UniProt Synonym Protein Names: | Endoplasmic reticulum resident protein 18; ER protein 18; ERp18; Endoplasmic reticulum resident protein 19; ER protein 19; ERp19; Thioredoxin-like protein p19; hTLP19 |
| Protein Family: | Thioredoxin domain-containing protein |
| UniProt Gene Name: | TXNDC12�� |
| UniProt Entry Name: | TXD12_HUMAN |
