Description
| Product Name: | Human TXN2 Recombinant Protein |
| Product Code: | RPPB5049 |
| Size: | 20µg |
| Species: | Human |
| Target: | TXN2 |
| Synonyms: | Thioredoxin mitochondrial, Thioredoxin-2, TXN2, MTRX, TRX2, MT-TRX, TRX-2, TXN-2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | TXN2 protein solution contains 1x PBS pH-7.4. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MTTFNIQDGP DFQDRVVNSE TPVVVDFHAQ WCGPCKILGP RLEKMVAKQH GKVVMAKVDI DDHTDLAIEY EVSAVPTVLA MKNGDVVDKF VGIKDEDQLE AFLKKLIG |
| Biological Activity: | Specific activity is 3-4 A650/min/mg, obtained by measuring the increase of�INS precipitation in absorbance at 650 nm resulting from the reduction of INS. |
Thioredoxin-2 is a low molecular weight redox protein. TRX2 contains a redox active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The TXN2 is involved in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. Upon stimulation of Fas, TXN2 mediates denitrosylation of mitochondria-associated caspase-3, a process required for caspase-3 activation, and promoted apoptosis. TRX2 is important at low oxidative stress conditions. MTRX is involved in the regulation of the mitochondrial membrane potential and cell death. Mitochondrial thioredoxin plays an important roles in protection against oxidant-induced apoptosis. Thioredoxin1 and thioredoxin2 have opposed regulatory functions on hypoxia-inducible factor-1alpha.
MTRX Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 108 amino acids and having a molecular mass of 11 kDa.
| UniProt Protein Function: | TXN2: Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity. Belongs to the thioredoxin family. |
| UniProt Protein Details: | Protein type:Oxidoreductase Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: cell soma; mitochondrion; mitochondrial matrix; dendrite; nucleolus Molecular Function:peptide-methionine-(S)-S-oxide reductase activity; protein complex binding; protein disulfide oxidoreductase activity; peptide-methionine (R)-S-oxide reductase activity Biological Process: response to drug; cellular response to nutrient levels; response to reactive oxygen species; cell redox homeostasis; response to hormone stimulus; response to glucose stimulus; response to hypoxia; response to axon injury; response to organic cyclic substance; glycerol ether metabolic process; response to nutrient |
| NCBI Summary: | This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99757 |
| NCBI GenInfo Identifier: | 20455529 |
| NCBI Gene ID: | 25828 |
| NCBI Accession: | Q99757.2 |
| UniProt Secondary Accession: | Q99757,Q5JZA0, Q6FH60, Q9UH29, |
| UniProt Related Accession: | Q99757 |
| Molecular Weight: | |
| NCBI Full Name: | Thioredoxin, mitochondrial |
| NCBI Synonym Full Names: | thioredoxin 2 |
| NCBI Official Symbol: | TXN2�� |
| NCBI Official Synonym Symbols: | MTRX; TRX2; MT-TRX�� |
| NCBI Protein Information: | thioredoxin, mitochondrial; thioredoxin-2; mitochondrial thioredoxin |
| UniProt Protein Name: | Thioredoxin, mitochondrial |
| UniProt Synonym Protein Names: | Thioredoxin-2 |
| UniProt Gene Name: | TXN2�� |
| UniProt Entry Name: | THIOM_HUMAN |
