Description
| Product Name: | Human TUSC2 Recombinant Protein |
| Product Code: | RPPB5042 |
| Size: | 20µg |
| Species: | Human |
| Target: | TUSC2 |
| Synonyms: | Tumor suppressor candidate 2, C3orf11, FUS1, PAP, PDAP2, TUSC2,Fusion 1 protein, Fus-1 protein, PDGFA-associated protein 2, LGCC. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The TUSC2 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMGASGSK ARGLWPFASA AGGGGSEAAG AEQALVRPRG RAVPPFVFTR RGSMFYDEDG DLAHEFYEET IVTKNGQKRA KLRRVHKNLI PQGIVKLDHP RIHVDFPVIL YEV |
Tumor Suppressor Candidate 2, also known as TUSC2, is a part of the TUSC2 family. TUSC2 protein functions as a tumor suppressor, inhibiting colony formation, causing G1 arrest and eventually inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.
TUSC2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 133 amino acids (1-110) and having a molecular mass of 14.5 kDa.TUSC2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TUSC2: May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells. Belongs to the TUSC2 family. |
| UniProt Protein Details: | Protein type:Tumor suppressor Chromosomal Location of Human Ortholog: 3p21.3 Cellular Component: mitochondrion Biological Process: interleukin-15 production; cell proliferation; negative regulation of interleukin-17 production; regulation of mitochondrial membrane potential; cell-cell signaling; natural killer cell differentiation; response to defense-related host reactive oxygen species production; cell maturation; cell cycle; inflammatory response; positive regulation of interleukin-10 production; phagocytosis |
| NCBI Summary: | This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75896 |
| NCBI GenInfo Identifier: | 7531123 |
| NCBI Gene ID: | 11334 |
| NCBI Accession: | O75896.3 |
| UniProt Secondary Accession: | O75896,B2R4Y9, |
| UniProt Related Accession: | O75896 |
| Molecular Weight: | 110 |
| NCBI Full Name: | Tumor suppressor candidate 2 |
| NCBI Synonym Full Names: | tumor suppressor candidate 2 |
| NCBI Official Symbol: | TUSC2�� |
| NCBI Official Synonym Symbols: | PAP; FUS1; PDAP2; C3orf11�� |
| NCBI Protein Information: | tumor suppressor candidate 2; fus-1 protein; fusion 1 protein; PDGFA associated protein 2; PDGFA-associated protein 2 |
| UniProt Protein Name: | Tumor suppressor candidate 2 |
| UniProt Synonym Protein Names: | Fusion 1 protein; Fus-1 protein; PDGFA-associated protein 2 |
| Protein Family: | Tumor suppressor candidate |
| UniProt Gene Name: | TUSC2�� |
| UniProt Entry Name: | TUSC2_HUMAN |
