Description
| Product Name: | Human TRIP10 Recombinant Protein |
| Product Code: | RPPB5010 |
| Size: | 20µg |
| Species: | Human |
| Target: | TRIP10 |
| Synonyms: | Cdc42-interacting protein 4, Protein Felic, Salt tolerant protein, hSTP, Thyroid receptor-interacting protein 10, TR-interacting protein 10, TRIP-10,TRIP10, CIP4, STOT, STP, HSTP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The TRIP10 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol, 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSDPKNDSH VLIELHKSGF ARPGDVEFED FSQPMNRAPS DSSLGTPSDG RPELRGPGRS RTKRWPFGKK NKTVVTEDFS HLPPEQQRKR LQQQLEERSR ELQKEVDQRE ALKKMKDVYE KTPQMGDPAS LEPQIAETLS NIERLKLEVQ KYEAWLAEAE SRVLSNRGDS LSRHARPPDP PASAPPDSSS NSASQDTKES SEEPPSEESQ DTPIYTEFDE DFEEEPTSPI GHCVAIYHFE GSSEGTISMA EGEDLSLMEE DKGDGWTRVR RKEGGEGYVP TSYLRVTLN |
Thyroid Hormone Receptor Interactor 10 (TRIP10) is a part of the F-BAR family of proteins which is expressed in a variety of tissues, including kidney, brain, liver, lung, heart and pancreas. The F-BAR family of proteins contains an N-terminal, alpha-helical, region which is hydrophobic and related to the Bin Amphiphysin Rvs (BAR) protein family. TRIP10 is vital for the coordination of membrane tubulation with Actin cytoskeletal reorganization during endocytosis.
TRIP10 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 309 amino acids (260-545) and having a molecular mass of 34.6 kDa.TRIP10 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TRIP10: Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N- WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. Belongs to the FNBP1 family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: nucleoplasm; Golgi apparatus; cell projection; cytoskeleton; intracellular membrane-bound organelle; lysosome; perinuclear region of cytoplasm; cytoplasm; cell cortex; cytosol; phagocytic cup Molecular Function:identical protein binding; protein binding; lipid binding Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; endocytosis; cell communication; actin cytoskeleton organization and biogenesis; signal transduction |
| UniProt Code: | Q15642 |
| NCBI GenInfo Identifier: | 118572632 |
| NCBI Gene ID: | 9322 |
| NCBI Accession: | Q15642.3 |
| UniProt Related Accession: | Q15642 |
| Molecular Weight: | 39kDa; 52kDa; 62kDa; 67kDa; 68kDa |
| NCBI Full Name: | Cdc42-interacting protein 4 |
| NCBI Synonym Full Names: | thyroid hormone receptor interactor 10 |
| NCBI Official Symbol: | TRIP10�� |
| NCBI Official Synonym Symbols: | STP; CIP4; HSTP; STOT; TRIP-10�� |
| NCBI Protein Information: | cdc42-interacting protein 4 |
| UniProt Protein Name: | Cdc42-interacting protein 4 |
| UniProt Synonym Protein Names: | Protein Felic; Salt tolerant protein; hSTP; Thyroid receptor-interacting protein 10; TR-interacting protein 10; TRIP-10 |
| Protein Family: | Cdc42-interacting protein |
| UniProt Gene Name: | TRIP10�� |
| UniProt Entry Name: | CIP4_HUMAN |
