Description
| Product Name: | Human TPD52L1 Recombinant Protein |
| Product Code: | RPPB4987 |
| Size: | 20µg |
| Species: | Human |
| Target: | TPD52L1 |
| Synonyms: | Tumor protein D53, Tumor protein D52-like 1, TPD52L1, hD53, D53, MGC8556, TPD52L2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | TPD52L1 protein solution (1mg/ml) containing 1xPBS pH 7.4. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MEAQAQGLLE TEPLQGTDED AVASADFSSM LSEEEKEELK AELVQLEDEI TTLRQVLSAK ERHLVEIKQK LGMNLMNELK QNFSKSWHDM QTTTAYKKTH ETLSHAGQKA TAAFSNVGTA ISKKFGDMRR K |
TPD52L1 (hD53, hD53L1) is a member of D52 gene family and overexpressed in human breast carcinoma. TPD52L1 contains coiled-coil motif, which is responsible for homo- and heteromeric interaction, and may be a regulator of cell proliferation and calcium-mediated signal transduction. Moreover, TPD52L1 interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis.
TPD52L1 Human Recombinant His-Tag fusion protein produced in E.Coli is a single, non-glycosylated polypeptide chain (21-151 a.a) containing amino acids 151 and having a molecular mass of 16.8 kDa.TPD52L1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TPD52L1: a member of the tumor protein D52 (TPD52) family. Contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. Interacts with the apoptosis signal-regulating kinase 1 (ASK1) and positively regulates ASK1-induced apoptosis. Multiple alternatively spliced transcript variants have been observed. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 6q22-q23 Cellular Component: perinuclear region of cytoplasm; cytoplasm Molecular Function:identical protein binding; protein binding; protein homodimerization activity; protein heterodimerization activity Biological Process: positive regulation of MAP kinase activity; positive regulation of JNK cascade; G2/M transition of mitotic cell cycle; regulation of caspase activity |
| NCBI Summary: | This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q16890 |
| NCBI GenInfo Identifier: | 12585368 |
| NCBI Gene ID: | 7164 |
| NCBI Accession: | Q16890.1 |
| UniProt Related Accession: | Q16890 |
| Molecular Weight: | |
| NCBI Full Name: | Tumor protein D53 |
| NCBI Synonym Full Names: | TPD52 like 1 |
| NCBI Official Symbol: | TPD52L1�� |
| NCBI Official Synonym Symbols: | D53�� |
| NCBI Protein Information: | tumor protein D53 |
| UniProt Protein Name: | Tumor protein D53 |
| UniProt Synonym Protein Names: | Tumor protein D52-like 1 |
| UniProt Gene Name: | TPD52L1�� |
| UniProt Entry Name: | TPD53_HUMAN |
