Description
system_update_altDatasheet
| Product name | Human TLR5 full length protein-synthetic nanodisc |
| Size: | 10ug |
| Product SKU: | HDFP124 |
| Product Category | Full Length Transmembrane Proteins |
| Target: | TLR5 |
| Uniprot: | O60602 |
| Description: | Human TLR5 full length protein-synthetic nanodisc |
| Molecular Weight: | The human full length TLR5 protein has a MW of 97.8 kDa |
| Protein Family: | Druggable Genome, Transmembrane |
| Protein Pathways: | Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Synonyms: | MELIOS; SLE1; SLEB1; TIL3 |
| Expression System: | HEK293 |
| Formulation: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| Background: | Toll-like receptor (TLR) family plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease. |
| Delivery: | In Stock |
| Usage | Research use only |
