Description
| Product Name: | Human TIAF1 Recombinant Protein |
| Product Code: | RPPB4957 |
| Size: | 10µg |
| Species: | Human |
| Target: | TIAF1 |
| Synonyms: | TGFB1-Induced Anti-Apoptotic Factor 1, 12 KDa TGF-Beta-1-Induced Antiapoptotic Factor, Molecule Associated With Jak-3 N-Terminal, KIAA0216, MYO18A, MYSPDZ, MAJN, SPR210. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The TIAF1 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMSS PSSPFREQSF LCAAGDAGEE SRVQVLKNEV RRGSPVLLGW VEQAYADKCV CGPSAPPAPT PPSLSQRVMC NDLFKVNPFQ LQQFRADPST ASLLLCPGGL DHKLNLRGKA WG |
TGFB1-induced anti-apoptotic factor 1 (TIAF1) hinders the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. The TIAF1 protein is involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. TIAF1 is not detected in normal kidney and liver. TIAF1 is up-regulated in chronic and acute allograft rejection: expressed in the inflammatory infiltrate and in tubular epithelial cells.
TIAF1 Human Recombinant produced in E. coli is a single polypeptide chain containing 152 amino acids (1-115) and having a molecular mass of 16.6 kDa.TIAF1 is fused to a 37 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TIAF1: Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: nucleus Biological Process: I-kappaB kinase/NF-kappaB cascade; apoptosis; negative regulation of apoptosis |
| UniProt Code: | O95411 |
| NCBI GenInfo Identifier: | 17978509 |
| NCBI Gene ID: | 9220 |
| NCBI Accession: | NP_004731 |
| UniProt Secondary Accession: | O95411,Q6PEG2, A2RRE2, |
| UniProt Related Accession: | O95411 |
| Molecular Weight: | 12,414 Da |
| NCBI Full Name: | TGFB1-induced anti-apoptotic factor 1 |
| NCBI Synonym Full Names: | TGFB1-induced anti-apoptotic factor 1 |
| NCBI Official Symbol: | TIAF1�� |
| NCBI Official Synonym Symbols: | MAJN; SPR210�� |
| NCBI Protein Information: | TGFB1-induced anti-apoptotic factor 1; TGF-beta-1-induced antiapoptotic factor 1; molecule associated with Jak-3 N-terminal; 12 kDa TGF-beta-1-induced antiapoptotic factor |
| UniProt Protein Name: | TGFB1-induced anti-apoptotic factor 1 |
| UniProt Synonym Protein Names: | 12 kDa TGF-beta-1-induced antiapoptotic factor |
| UniProt Gene Name: | TIAF1�� |
| UniProt Entry Name: | TIAF1_HUMAN |
