Description
| Product Name: | Human TFPI2 Recombinant Protein |
| Product Code: | RPPB4939 |
| Size: | 5µg |
| Species: | Human |
| Target: | TFPI2 |
| Synonyms: | Tissue Factor Pathway Inhibitor 2, Placental Protein 5, TFPI-2, PP5, Retinal Pigment Epithelium Cell Factor 1, REF1, TFPI2. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | TFPI2 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | DAAQEPTGNN AEICLLPLDY GPCRALLLRY YYDRYTQSCR QFLYGGCEGN ANNFYTWEAC DDACWRIEKV PKVCRLQVSV DDQCEGSTEK YFFNLSSMTC EKFFSGGCHR NRIENRFPDE ATCMGFCAPK KIPSFCYSPK DEGLCSANVT RYYFNPRYRT CDAFTYTGCG GNDNNFVSRE DCKRACAKAL KLEHHHHHH |
TFPI2 takes part in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. TFPI2 doesn�t have any influence on thrombin.
TFPI2 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 199 amino acids (23-213 a.a.) and having a molecular mass of 22.9kDa (Migrates at 18-40kDa on SDS-PAGE under reducing conditions).TFPI2 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TFPI2: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 7q22 Cellular Component: proteinaceous extracellular matrix; nucleus Molecular Function:serine-type endopeptidase inhibitor activity; extracellular matrix structural constituent Biological Process: blood coagulation |
| NCBI Summary: | This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
| UniProt Code: | P48307 |
| NCBI GenInfo Identifier: | 1351226 |
| NCBI Gene ID: | 7980 |
| NCBI Accession: | P48307.1 |
| UniProt Secondary Accession: | P48307,Q66ME8, Q8NAK6, Q9UC86, |
| UniProt Related Accession: | P48307 |
| Molecular Weight: | 25,796 Da |
| NCBI Full Name: | Tissue factor pathway inhibitor 2 |
| NCBI Synonym Full Names: | tissue factor pathway inhibitor 2 |
| NCBI Official Symbol: | TFPI2�� |
| NCBI Official Synonym Symbols: | PP5; REF1; TFPI-2�� |
| NCBI Protein Information: | tissue factor pathway inhibitor 2; placental protein 5; retinal pigment epithelium cell factor 1 |
| UniProt Protein Name: | Tissue factor pathway inhibitor 2 |
| UniProt Synonym Protein Names: | Placental protein 5; PP5 |
| Protein Family: | Tissue factor pathway inhibitor |
| UniProt Gene Name: | TFPI2�� |
| UniProt Entry Name: | TFPI2_HUMAN |
