Description
| Product Name: | Human TCL1A Recombinant Protein |
| Product Code: | RPPB4928 |
| Size: | 50µg |
| Species: | Human |
| Target: | TCL1A |
| Synonyms: | T-cell leukemia/lymphoma protein 1A, Protein p14 TCL1, Oncogene TCL-1, Oncogene TCL1, TCL1A, TCL1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The TCL1A protein solution contains 50mM Tris-HCl buffer (pH7.5) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MAECPTLGEA VTDHPDRLWA WEKFVYLDEK QHAWLPLTIE IKDRLQLRVL LRREDVVLGR PMTPTQIGPS LLPIMWQLYP DGRYRSSDSS FWRLVYHIKI DGVEDMLLEL LPDD |
TCL1A (T-cell leukemia/lymphoma 1A) is a protein with a possible role in intracellular regulation of T cell signaling. TCL1A enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. TCL1A is restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. TCL1A is preferentially expressed early in T and B-lymphocyte differentiation. Chromosomal anomalies activating TCL1A are found in chronic T-cell leukemias (T-CLL). TCL1A enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. TCL1A promotes nuclear translocation of AKT1. TCL1A binds to the pleckstrin homology domain of Akt (protein kinase B) family proteins, which facilitates Akt dimerization and activity. By increasing Akt activity, TCL1A can enhance the serine/threonine phosphorylation of major Akt signaling substrates, for example Ikk complex, mTOR, BAD, p70S6 kinase, FOXO transcription factors and GSK3b. These substrates regulate cellular differentiation, growth, survival, and metabolism.
TCL1A Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 114 amino acids (1-114 a.a.) and having a molecular mass of 13.4kDa.The TCL1A is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TCL1A: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity. Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation. Belongs to the TCL1 family. |
| UniProt Protein Details: | Protein type:Oncoprotein; Protein kinase, regulatory subunit Chromosomal Location of Human Ortholog: 14q32.1 Cellular Component: endoplasmic reticulum; pronucleus; cell cortex Molecular Function:protein binding Biological Process: multicellular organismal development; stem cell maintenance |
| NCBI Summary: | Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010] |
| UniProt Code: | P56279 |
| NCBI GenInfo Identifier: | 3024699 |
| NCBI Gene ID: | 8115 |
| NCBI Accession: | P56279.1 |
| UniProt Related Accession: | P56279 |
| Molecular Weight: | |
| NCBI Full Name: | T-cell leukemia/lymphoma protein 1A |
| NCBI Synonym Full Names: | TCL1 family AKT coactivator A |
| NCBI Official Symbol: | TCL1A�� |
| NCBI Official Synonym Symbols: | TCL1�� |
| NCBI Protein Information: | T-cell leukemia/lymphoma protein 1A |
| UniProt Protein Name: | T-cell leukemia/lymphoma protein 1A |
| UniProt Synonym Protein Names: | Oncogene TCL-1; Oncogene TCL1; Protein p14 TCL1 |
| Protein Family: | MYB-like transcription factor |
| UniProt Gene Name: | TCL1A�� |
| UniProt Entry Name: | TCL1A_HUMAN |
