Description
| Product Name: | Human TCEAL7 Recombinant Protein |
| Product Code: | RPPB4924 |
| Size: | 20µg |
| Species: | Human |
| Target: | TCEAL7 |
| Synonyms: | Transcription elongation factor A (SII)-like 7, TCEA-like protein 7, transcription elongation factor A protein-like 7, MGC23947, MPMGp800C04260Q003. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The TCEAL7 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 50% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMQKPCK ENEGKPKCSV PKREEKRPYG EFERQQTEGN FRQRLLQSLE EFKEDIDYRH FKDEEMTREG DEMERCLEEI RGLRKKFRAL HSNHRHSRDR PYPI |
Transcription Elongation Factor A (SII)-Like 7 (TCEAL7) has a role in the negative regulation of NF-kappa-B signaling at the basal level by controlling transcriptional activity of NF-kappa-B on its target gene promoters. TCEAL7 links with cyclin D1 promoter containing Myc E-box sequence and transcriptionally inhibits cyclin D1 expression. TCEAL7 regulates telomerase reverse transcriptase expression and telomerase activity in both alternative lengthening of telomeres (ALT) and telomerase-positive cell lines. TCEAL7 is highly expressed in normal and fetal brain tissues, and weakly expressed in the uterus and ovary. TCEAL7 is down-regulated in epithelial ovarian, cervical, prostate, breast, brain and lung cancer cell lines and in the brain and ovarian tumors.
TCEAL7 Human Recombinant produced in E. coli is a single polypeptide chain containing 124 amino acids (1-100) and having a molecular mass of 14.8 kDa.TCEAL7 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TCEAL7: Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines. Belongs to the TFS-II family. TFA subfamily.Chromosomal Location of Human Ortholog: Xq22.1Cellular Component: nucleusBiological Process: transcription, DNA-dependent; inhibition of NF-kappaB transcription factor; negative regulation of transcription, DNA-dependent |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9BRU2 |
| NCBI GenInfo Identifier: | 23397409 |
| NCBI Gene ID: | 56849 |
| NCBI Accession: | NP_689491.1 |
| UniProt Secondary Accession: | Q9BRU2 |
| UniProt Related Accession: | Q9BRU2 |
| Molecular Weight: | |
| NCBI Full Name: | transcription elongation factor A protein-like 7 |
| NCBI Synonym Full Names: | transcription elongation factor A like 7 |
| NCBI Official Symbol: | TCEAL7�� |
| NCBI Official Synonym Symbols: | WEX5�� |
| NCBI Protein Information: | transcription elongation factor A protein-like 7 |
| UniProt Protein Name: | Transcription elongation factor A protein-like 7 |
| UniProt Synonym Protein Names: | Transcription elongation factor S-II protein-like 7 |
| Protein Family: | |
| UniProt Gene Name: | TCEAL7�� |
| UniProt Entry Name: | TCAL7_HUMAN |
