Description
| Product Name: | Human TBCEL Recombinant Protein |
| Product Code: | RPPB4919 |
| Size: | 20µg |
| Species: | Human |
| Target: | TBCEL |
| Synonyms: | Tubulin Folding Cofactor E-Like, E-Like, LRRC351, Leucine Rich Repeat Containing Catastrophin, Tubulin-Specific Chaperone E-Like. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The TBCEL solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) 0.15M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMDQPSGR SFMQVLCEKY SPENFPYRRG PGMGVHVPAT PQGSPMKDRL NLPSVLVLNS CGITCAGDEK EIAAFCAHVS ELDLSDNKLE DWHEVSKIVS NVPQLEFLNL SSNPLNLSVL ERTCAGSFSG VRKLVLNNSK ASWETVHMIL QELPDLEELF�LCLNDYETVS CPSICCHSLK LLHITDNNLQ DWTEIRKLGV MFPSLDTLVL ANNHLNAIEE PDDSLARLFP NLRSISLHKS GLQSWEDIDK �LNSFPKLEEV RLLGIPLLQP YTTEERRKLV IARLPSVSKL NGSVVTDGER EDSERFFIRY YVDVPQEEVP FRYHELITKY GKLEPLAEVD�LRPQSSAKVE VHFNDQVEEM SIRLDQTVAE LKKQLKTLVQ LPTSNMLLYY FDHEAPFGPE EMKYSSRALH SFGIRDGDKI YVESKTK |
TBCEL, is a factor that is in charge of the microtubule cytoskeleton in determining cell behavior. TBCEL plays a role as a regulator of tubulin stability. While widely expressed in testis, TBCEL is also present in several tissues at a much lower level. TBCEL comprises of seven LRR (leucine-rich) repeats, one LRRCT domain and one ubiquitin-like domain. The gene that translates TBCEL consists of 66,704 bases and maps to human chromosome 11q23.3. Chromosome 11 houses over 1,400 genes and consist of nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that map to chromosome 11.
TBCEL �Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 447 amino acids and having a molecular mass of 50.6kDa.�The TBCEL is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LRRC35: Acts as a regulator of tubulin stability.Chromosomal Location of Human Ortholog: 11q23.3Molecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q5QJ74 |
| NCBI GenInfo Identifier: | 215273924 |
| NCBI Gene ID: | 219899 |
| NCBI Accession: | Q5QJ74.2 |
| UniProt Secondary Accession: | Q5QJ74,Q0VAN6 |
| UniProt Related Accession: | Q5QJ74 |
| Molecular Weight: | 48,195 Da |
| NCBI Full Name: | Tubulin-specific chaperone cofactor E-like protein |
| NCBI Synonym Full Names: | tubulin folding cofactor E like |
| NCBI Official Symbol: | TBCEL�� |
| NCBI Official Synonym Symbols: | El; LRRC35�� |
| NCBI Protein Information: | tubulin-specific chaperone cofactor E-like protein |
| UniProt Protein Name: | Tubulin-specific chaperone cofactor E-like protein |
| UniProt Synonym Protein Names: | Leucine-rich repeat-containing protein 35 |
| Protein Family: | Tubulin-specific chaperone cofactor E-like protein |
| UniProt Gene Name: | TBCEL�� |
| UniProt Entry Name: | TBCEL_HUMAN |
