Description
| Product Name: | Human TARDBP (1-414) Recombinant Protein |
| Product Code: | RPPB4909 |
| Size: | 5µg |
| Species: | Human |
| Target: | TARDBP (1-414) |
| Synonyms: | ALS10,TDP43, TAR DNA-binding protein 43, TDP-43, TARDBP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | TARDBP protein solution (0.25mg/ml) containing 20mM Tris-HCl (pH8.0), 1mM DTT, 0.1M NaCl, 10% glycerol and 1mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA QSLCGEDLII KGISVHISNA EPKHNSNRQL ERSGRFGGNP GGFGNQGGFG NSRGGGAGLG NNQGSNMGGG MNFGAFSINP AMMAAAQAAL QSSWGMMGML ASQQNQSGPS GNNQNQGNMQ REPNQAFGSG NNSYSGSNSG AAIGWGSASN AGSGSGFNGG FGSSMDSKSS GWGM |
TARDNA Binding Protein (TARDBP) was initially recognized as a transcriptional repressorwhich binds to chromosomally integrated TAR DNA and represses HIV-1transcription. In addition, TARDBP has been detected in individuals diagnosedwith chronic traumatic encephalopathy as well, which is a condition that oftenimitates ALS and hasbeen related with athletes who have experienced multiple concussions and othertypes of head injury.TARDBPhas been shown to bind both DNA and RNA, it has multiple functions intranscriptional repression, pre-mRNA splicing and translational regulation.
TARDBP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 414 amino acids (1-414 a.a) and having a molecular mass of 44.7kDa.TARDBP is purified by proprietary chromatographic techniques.
| NCBI Summary: | HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13148 |
| NCBI GenInfo Identifier: | 20140568 |
| NCBI Gene ID: | 23435 |
| NCBI Accession: | |
| UniProt Related Accession: | Q13148 |
| Molecular Weight: | 44 |
| NCBI Full Name: | TAR DNA-binding protein 43 |
| NCBI Synonym Full Names: | TAR DNA binding protein |
| NCBI Official Symbol: | TARDBP�� |
| NCBI Official Synonym Symbols: | ALS10; TDP-43�� |
| NCBI Protein Information: | TAR DNA-binding protein 43 |
| UniProt Protein Name: | |
| UniProt Gene Name: |
