Description
| Product Name: | Human SYCE3 Recombinant Protein |
| Product Code: | RPPB4884 |
| Size: | 10µg |
| Species: | Human |
| Target: | SYCE3 |
| Synonyms: | Synaptonemal complex central element protein 3, chromosome 22 open reading frame 41, Testis highly expressed gene 2 protein, testis highly expressed protein 2, THEG2, C22orf41. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SYCE3 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MDDADPEERN YDNMLKMLSD LNKDLEKLLE EMEKISVQAT WMAYDMVVMR TNPTLAESMR RLEDAFVNCK EEMEKNWQEL LHETKQRL |
Synaptonemal complex central element protein 3 (SYCE3) is key component of the transverse central element of synaptonemal complexes (SCS). The synaptonemal complex is a protein structure which forms between homologous chromosomes (2 pairs of sister chromatids) during meiosis and is assumed to mediate chromosome pairing, synapsis, and recombination (crossing-over). The SYCE3 protein is essential for chromosome loading of the central element-specific SCS proteins, as well as for initiating synapsis between homologous chromosomes. SYCE3 is also vital for fertility.
SYCE3 Human Recombinant produced in E. coli is a single polypeptide chain containing 108 amino acids (1-88) and having a molecular mass of 12.8 kDa.SYCE3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SYCE3: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility.Chromosomal Location of Human Ortholog: 22q13.33Cellular Component: central element; chromosome; nucleusBiological Process: synaptonemal complex assembly; cell division; positive regulation of apoptosis; meiotic recombination; spermatogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | A1L190 |
| NCBI GenInfo Identifier: | 178557813 |
| NCBI Gene ID: | 644186 |
| NCBI Accession: | NP_001116697.1 |
| UniProt Secondary Accession: | A1L190 |
| UniProt Related Accession: | A1L190 |
| Molecular Weight: | 10,601 Da |
| NCBI Full Name: | synaptonemal complex central element protein 3 |
| NCBI Synonym Full Names: | synaptonemal complex central element protein 3 |
| NCBI Official Symbol: | SYCE3�� |
| NCBI Official Synonym Symbols: | THEG2; C22orf41�� |
| NCBI Protein Information: | synaptonemal complex central element protein 3; testis highly expressed gene 2 protein; testis highly expressed protein 2 |
| UniProt Protein Name: | Synaptonemal complex central element protein 3 |
| UniProt Synonym Protein Names: | Testis highly expressed gene 2 protein; THEG-2 |
| Protein Family: | Synaptonemal complex central element protein |
| UniProt Gene Name: | SYCE3�� |
| UniProt Entry Name: | SYCE3_HUMAN |
